A new chromophore, 2-(4-nitrophenyl)-1H-indole (NPI), was synthesized as a potential photolabile protecting group. Caged benzoic acids featuring the NPI chromophore were model compounds. Benzoic acid released in moderate yields (~ 40–60%) upon photolysis of caged without any additional chemical reagents. Interestingly, an aldehyde, 1-(5-(1-formyl-1H-indol-2-yl)-2-nitrophenyl)ethyl benzoate, iso...

Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) and coxibs are traditional medicines for the treatment of inflammation, yet associated with serious side effects. Hence, need discovering novel compounds valuable clinical benefits is great importance. In this study, 18 derivatives p-nitrophenyl hydrazones were docked against COX-2, 5-LOX, H+/K+ ATPase, followed by predicting their drug-lik...

The following Supporting Methods describe determination of the charge density on each nonbridging oxygen atom and catalytic proficiencies for the R166S AP-catalyzed reactions of the following substrates: para-nitrophenyl phosphate (pNPP), para-nitrophenyl phosphorothioate (pNPPS), bis-(para-nitrophenyl) phosphate (bpNPP), methyl para-nitrophenyl phosphate (MpNPP), methyl para-nitrophenyl phosph...

Microbial enzymes are important tools that frequently used in the field of biotechnology. These microbial enzymes, which play a role intracellular biological reactions, many different industries. Lipase, proteases and amylases members hydrolytic enzymes. Lipase enzyme, has most common usage area among is an enzyme catalyzes hydrolysis ester bonds between lipid molecules. The activity lipase com...

The reaction of 1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (1) with excess hydroxylamine hydrochloride (2 mole equivalents) in dry ethanol afforded (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one oxime (2) 86% yield. structure the new heterocycle 2 was confirmed using nuclear magnetic resonance spectroscopy, single crystal X-ray and elemental analysis.

Abstract A series of 1,3,4-thiadiazole derivatives were designed and synthesized using N -(4-nitrophenyl)acetohydrazonoyl bromide 1-[3,5-dimethyl-1-(4-nitrophenyl)-1 H -pyrazol-4-yl]ethan-1-one as starting materials. The treatment with methyl hydrazinecarbodithioate or hydrazinecarbothioamide afforded 2-[1-[5-methyl-1-(4-nitrophenyl)-1 -pyrazol-4-yl]ethylidene]hydrazine derivatives. targeted 1,...

The present study describes synthesis of a series of 2-phenyl benzimidazole-1-acetamide derivatives and their evaluation for anthelmintic activity using Indian adult earthworms, Pheretima posthuma. The structure of the title compounds was elucidated by elemental analysis and spectral data. The compounds 4-({[2-(4-nitrophenyl)-1H-benzimidazol-1-yl]acetyl}amino) benzoic acid (3a), N-ethyl-2-[2-(4...