endo-derived nitric oxide (no) is synthesized from l-arginine by endothelium nitric oxide synthase (enos). since reduced no synthesis has been implicated in the development of coronary atherosclerosis; we hypothesized that polymorphisms of nos gene might be associated with increased susceptibility to this disorder and coronary artery disease (cad). we studied the 27 base pair tandem repeat poly...

nitric oxide is an important vasorelaxant factor that it inhibits platelet adhesion and proliferation of smooth muscle cells. no is synthesized from l-arginine by means of endothelial nitric oxide synthase (enos) which is an isoform of  nitric oxide synthase.in the present study, we examined  possible association between the 27 base pair (bp) repeat  polymorphism in intron 4 of the  enos3 gene ...

various polymorphisms on endothelial nitric oxide synthase (enos) gene cause reduced production of no, the endothelial relaxing factor, and may accelerate the process of atherosclerosis. the study designed to investigate the frequency of t-786c polymorphism of the enos gene in patients suffering from coronary artery disease (cad) in north-west of iran. one hundred twenty subjects including 60 p...

objective(s):the neuropeptide calcitonin gene-related peptide (cgrp) has long been postulated to play an integral role in the pathophysiology of migraine. earlier studies showed that cgrp can stimulate the synthesis and release of nitric oxide (no) and cytokines from trigeminal ganglion glial cells. the purpose of this study was to determine the effect of 17β-estradiol in regulation of cgrp exp...

the genus artemisia is estimated to comprise over 800 species with anti-cancer, anti-fungal, anti-oxidant and anti-inflammatory properties. artemisia fragrans ( a. fragrans ), a species that belongs to genus artemisia , is rich in monoterpenes and sesquiterpenes derivatives. due to anti-inflammatory properties of monoterpenes and sesquiterpenes, we aimed to investigate the effect of a. fragrans...

nitric oxide is a short-lived mediator, which can be induced in a variety of cell types and produces many physiologic and metabolic changes in target cells. it is important in many biological functions and generated from l-arginine by the enzyme nitric oxide synthase. nitric oxide conveys a variety of messages between cells, including signals for vasorelaxation, neurotransmission and cytotoxici...

BACKGROUND Endothelial nitric oxide synthase produces nitric oxide which is involved in many physiologic regulatory functions. Variable number of tandem repeats in intron 4 of endothelial nitric oxide synthase gene are reported to be associated with blood pressure regulation. Nitric oxide is involved in regulation of cardiomyocyte genes but it is not known If endothelial nitric oxide synthase 4...

background: during the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. this is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. arginase competes with inducible nitric oxide synthase for a common substrate l-arginine. objective: to investigate whethe...

BACKGROUND Bypass graft disease is related to proliferation and migration of vascular smooth muscle cells and to platelet activation with thrombus formation. Nitric oxide inhibits these biological responses; it has never been demonstrated, however, whether this occurs in intact human vascular tissue after endothelial nitric oxide synthase gene transfer. METHODS We examined whether endothelial...