This study evaluated the effects of Newbouldia laevis and Cassia abbreviata extracts on CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were used for evaluating inhibition, allowing the assessment of herb-drug interactions (HDI). Phytochemical fingerprinting was performed using UPLC-MS. The herbal extracts were risk ranked for HDI based on the IC50 values determined...

Background: Newbouldia laevis and Crateva adansonii are popular plants used traditionally in the management of patients with malaria infection in Nigeria. In this study, the acute toxicity and anti-plasmodial effects of the leaf extracts of Newbouldia laevis and Crateva adansonii were investigated in mice. Methods: The Anti-plasmodial activities of both extracts were investigated individual...

objective: newbouldia laevis seem, is an ubiquitous perennial plant belonging to the family bignoniaceae with varying applicability in ethnomedicine. methods: the anticonvulsant effect of the aqueous extracts of root and stem bark preparations was undertaken using standard techniques. results: results showed that the ld50 in mice was 489.8mg/kg body weight while 5.6mg/kg body weight protected m...

Objective: Newbouldia laevis Seem, is an ubiquitous perennial plant belonging to the family Bignoniaceae with varying applicability in ethnomedicine. Methods: The anticonvulsant effect of the aqueous extracts of root and stem bark preparations was undertaken using standard techniques. Results: Results showed that the LD50 in mice was 489.8mg/kg body weight while 5.6mg/kg bod...

Objective: Newbouldia laevis Seem, is an ubiquitous perennial plant belonging to the family Bignoniaceae with varying applicability in ethnomedicine. Methods: The anticonvulsant effect of the aqueous extracts of root and stem bark preparations was undertaken using standard techniques. Results: Results showed that the LD50 in mice was 489.8mg/kg body weight while 5.6mg/kg bod...

Following studies made on the standardization of a traditional recipe Albizia ferruginea and Newbouldia laevis, we carried out pharmacological effects microorganisms found dermatosis: two bacteria Staphylococcus aureus, Pseudomonas aeruginosa three species Epidermophyton. Materials Methods: harvest truck pulps laevis at Eloundem, they were dry for week in an ambient environment, followed by gri...

The continuous use of plants in folklore for reproductive health has prompted the need to search for plants with fertility enhancement or anti-fertility potentials. Hence, the effect of oral administration of aqueous extract of Newbouldia laevis leaves for twenty one (21) days on reproductive hormones of albino male rats was investigated. Twelve male albino rats were grouped into three (A, B an...

Poverty, drug resistance and other factors including increasing difficulty in the control of mosquitoes (the vector of the causative organism of malaria), have led to a growing interest in phytochemical research. The antioxidant activity of Newbouldia laevis stem bark was investigated. Air dried stem bark of N. laevis was powdered and extracted with 95 % v/v methanol by maceration, and the extr...

Highly active antiretroviral therapy (HAART) has greatly improved health parameters of HIV infected individuals. However, there are several challenges associated with the chronic nature of HAART administration. For populations in health transition, dual use of medicinal plant extracts and conventional medicine poses a significant challenge. There is need to evaluate interactions between commonl...