background: echinococcosis is a zoonotic parasitic disease of humans and various herbivorous domestic animals transmitted by the contact with domestic and wild carnivores,mainly dogs and foxes. the aim of this study is the production, purification and evaluation immunogenicity of new construction of eg95 protein. methods: the recombinant plasmid pet32-a+ used for eg95 expression was constructed...

lipoprotein (a) [lp (a) is formed by assembly of ldl-particles and the carbohydrate rich protein, apolipoprotein (a) [apo (a)]. elevated plasma lp (a) levels are an independent predictor of the development of premature coronary artery disease (cad), but is not clear whether the apo (a) isoform plays on additional and independent role or not. to investigate the possible effect of apo (a) isoform...

objective(s):previous studies demonstrate that changes in pre-mrna splicing play a significant role in human disease development. furthermore, many cancer-associated genes are regulated by alternative splicing. there are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. located on the x chromosome, ...

Background Environmental and cellular inappropriate conditions can cause damages to cells nucleotide poll. Deamination and oxidation damages interfere with cell�s vital reactions. Inosine triphosphate pyrophosphatase (ITPA), an evolutionary conserved enzyme, plays a critical role in elimination of non-canonical bases. In human genome, the ITPA gene is located on chromosome 20 short arm and tran...

Objective(s):Previous studies demonstrate that changes in pre-mRNA splicing play a significant role in human disease development. Furthermore, many cancer-associated genes are regulated by alternative splicing. There are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. Located on the X chromosome, ...

in order to study and compare the phosphate transporter gene codon usage and it's respond to the traits like salt tolerance, day length, pollination and temperature in different plants, 100 isoform from 10 plants are extracted from ncbi website and then analyzed with gene infinity and minitab 16 software. the result shows that the highest codon usage similarity (81.95%) was for wheat and oryza ...

Mitochondria membrane protein-associated neurodegeneration (MPAN) neurodegenerative disorder is typically associated with biallelic C19orf12 variants. Here we describe a new and review candidate previous monoallelic de novo variants to define loss of function mutations located in the putative non-membrane spanning isoform as potential basis MPAN.

BACKGROUND The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to the region where the A and B isoforms differ. The aim of this study was to investigate the importance of the C-terminus of the B chain in IR isofo...