alcohol provokes different molecular pathways contributing to a clinically significant neurotoxicity in different brain areas. affected cognition in alcoholics can influence both daily life functioning and alcohol craving management abilities. preventing alcohol-induced neurotoxicity with different neuroprotective pharmacological interventions is receiving strong scientific backgrounds from pub...

conclusions as green tea is an essential source of antioxidants such as flavonoids, suppression of reactive oxygen species (ros) generation may be in part considered as the neuroprotective mechanism on acr induced neurotoxicity. background acrylamide (acr) monomer is an effective neurotoxicant, which damages the central and peripheral nervous systems in humans and animals. green tea, an infusio...

background: the use of organophosphates (ops) in developing countries is rising in large quantities and non-secure methods. this problem not only causes acute poisoning but also may lead to chronic diseases such as polyneuropathy. in iran, 60% of pesticides are organophosphate compounds that may lead to delayed polyneuropathy. objectives: the purpose of the current study was to evaluate delayed...

Alcohol provokes different molecular pathways contributing to a clinically significant neurotoxicity in different brain areas. Affected cognition in alcoholics can influence both daily life functioning and alcohol craving management abilities. Preventing alcohol-induced neurotoxicity with different neuroprotective pharmacological interventions is receiving strong scientific backgrounds from pub...

Article history: Received 3 October 2016 Accepted 3 October 2016 Available online 6 October 2016 sleep-wake cycle (Tononi and Cirelli, 2014). In addition to possible alterations in synaptic volume and number, significant changes in the interstitial brain space during sleep have also been shown (Xie et al., 2013). For example, a recently discovered glymphatic system appears to act during sleep a...

Humans are exposed to a variety of chemicals including environmental pollutants, cosmetics, food preservatives and drugs. Some of these substances might be harmful to the human body. Traditional toxicological and behavioural investigations performed in animal models are not suitable for the screening of a large number of compounds for potential toxic effects. There is a need for simple and robu...

To whom correspondence should be addressed. Leila M. Luheshi, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK, [email protected]; Damian. C. Crowther, Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK, [email protected]; Christopher M. Dobson, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, C...

Individuals suffering from human immunodeficiency virus type 1 (HIV-1) infection suffer from a wide range of neurological deficits. The most pronounced are the motor and cognitive deficits observed in many patients in the latter stages of HIV infection. Gross postmortem inspection shows cortical atrophy and widespread neuronal loss. One of the more debilitating of the HIV-related syndromes is A...