mesenchymal stem cells (mscs) have the ability to differentiate into neuronal like cells under appropriate culture condition. in this study, we investigated whether mscs derived from human peripheral blood (pb-mscs) can differentiate into neuronal like cells by synergic effect of the growth factors egf, bfgf and noggin. for this purpose, the expression of five neuronal markers (nestin, β iii tu...

human umbilical cord matrix (hucm) is considered as a promising source of mesenchymal stem cells (mscs) due to several advantages over other tissues. the potential of neural differentiation of hucm-mscs is of great interest in the context of treating neurodegenerative diseases. in recent years, considerable efforts have been made to establish in vitro conditions for improving the differentiatio...

Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. In vitro and animal studies have linked neuroinflammation to Alzheimer's disease (AD) pathology. Studies on marke...

alzheimer disease (ad) is a neurodegenerative disorder and the most common form of dementia. increasing evidence suggests that alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. in vitro and animal studies have linked neuroinflammation to alzheimer's disease (ad) pathology. studie...

Human umbilical cord matrix (hUCM) is considered as a promising source of mesenchymal stem cells (MSCs) due to several advantages over other tissues. The potential of neural differentiation of hUCM-MSCs is of great interest in the context of treating neurodegenerative diseases. In recent years, considerable efforts have been made to establish in vitro conditions for improving the different...

Objective(s): Epilepsy establishment gives rise to biochemical and morphological changes in the hippocampus. Oxidative stress, morphological changes, and mossy fiber sprouting (MFS) in the hippocampus underpin the epilepsy establishment. Eugenol is the main component of the essential oil extracted from cloves with the potential to modulate neuronal excitability. Therefore, we investigated the e...

Mesenchymal stem cells (MSCs) have the ability to differentiate into neuronal like cells under appropriate culture condition. In this study, we investigated whether MSCs derived from human peripheral blood (PB-MSCs) can differentiate into neuronal like cells by synergic effect of the growth factors EGF, bFGF and Noggin. For this purpose, the expression of five neuronal markers (Nestin, &beta II...

introduction: there are the evidences to suggest that bone marrow stromal cells (bmscs) not only differentiate into mesodermal cells, but also adopt the fate of endodermal and ectodermal cell types. bmscs can be a valuable cell source as an autograph for clinical application involving regeneration of the central nervous system. bone marrow stromal cells can be expanded rapidly in vitro and have...