based on both animal and human studies, inequality in food intake and social instability has adverse effects on the health of individuals and the community. however, it is not known whether social instability, food deprivation and food inequality affect neuronal death and premature aging in young animals. to address this question, the effects of these adverse situations, histopathological chang...

neuronal and astroglial cells were prepared from whole brain of three month and 30-month- old rats for study of alterations in the nuclear poly adp-ribosylation and dna breaks with age. the relative purity of the cell preparations was confirmed by the determination of the neurofilament (low molecular weight) and glutamine synthetase content of the cells using elisa. an increase (75%) in the pol...

Aging brains undergo cognitive decline, associated with decreased neuronal synapse number and function and altered metabolism. Astrocytes regulate neuronal synapse formation and function in development and adulthood, but whether these properties change during aging, contributing to neuronal dysfunction, is unknown. We addressed this by generating aged and adult astrocyte transcriptomes from mul...

AIM To observe the effect of cholecystokinin (CCK) on lipofusin value, neuronal dendrite and spine ultrastructure, and total cellular protein during the process of experimental neuronal aging. METHODS Experimental neuronal aging study model was established by NBA2 cellular serum-free culture method. By using single intracellular lipofusin value from microspectrophotometry, morphology of neuro...

Neuronal and astroglial cells were prepared from whole brain of three month and 30-month- old rats for study of alterations in the nuclear poly ADP-ribosylation and DNA breaks with age. The relative purity of the cell preparations was confirmed by the determination of the neurofilament (low molecular weight) and glutamine synthetase content of the cells using ELISA. An increase (75%) in th...

The main risk factor for neurodegenerative disorders, like Alzheimer disease, is aging. At molecular level, aging correlates, in peripheral tissues and the central nervous system with epigenetic changes at chromatin (histones DNA) of aged cells. These can be reverted by expression the, so called, Yamanaka factors (YF). YF reprogram (rejuvenate) old cells to structural functional characteristics...

Alzheimer’s disease is one of the most prevalent neurodegenerative diseases in world which mostly appears with aging [1,2]. Neuronal death, followed by cognitive decline and memory loss serve as an important outcome [3].