THE IMPORTANCE OF PROVIDING ADEQUATE TREATMENT FOR SCHIZOPHRENIA SOMATIC THERAPIES Pharmacologic Background The Introduction of Chlorpromazine The Dopamine Hypothesis Overview of Treatment Issues The Older “Classical” Neuroleptics What are the Target Symptoms for Neuroleptics Adverse Effects The Newer “Atypical” or “Second Generation” Neuroleptics Pharmacology of “Second Generation” Neuroleptic...

We have reviewed the literature from the 1950's to the present on the effects of neuroleptics on perceptual and neuropsychological function in chronic schizophrenic patients. In contrast to previous reviews, we have delineated the acute and chronic effects of neuroleptics on individual cognitive and motor tasks by drug, dose, and length of administration. To date, studies have shown that acute ...

The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the activity of cytochrome P450 2C11 (CYP2C11), measured as a rate of testosterone 2α- and 16α-hydroxylation. The reaction was studied in control liver microsomes in the presence of neuroleptics, as well as in the microsomes of rats treated intraperitoneally (ip) with pharmacological doses of t...

Abstract Introduction Sedative medications are commonly prescribed for older adults; these include neuroleptics, benzodiazepines, opioids, ‘z’ drugs and trazadone. The prevalence of sedative drug prescriptions is increasing (1). Nursing home residents three times more likely to be benzodiazepines (2). Regular medication review education have been shown reduce rates use in nursing homes (3). We ...

OBJECTIVE The development of both type I and type II diabetes after initiation of some atypical neuroleptics has been reported, primarily in studies involving small series of patients. This study used administrative data from a large national sample of patients with a diagnosis of schizophrenia to compare the prevalence of diabetes mellitus in patients receiving prescriptions for atypical and t...