introduction: ms disease destroys the myelin of the central nervous system. ms causing damage to the myelin sheath of the brain and the spinal cord. the mechanism is hurt by the immune system .and disruption of myelin producing cells or disconnect interconnected processes by disconnect inner white. ms is an autoimmune disease when leukocyte antigen system varies autoimmune disease like ms sprea...

traumatic brain injury (tbi) is a common reason of brain tissue loss as a result of tumors, accidents, and surgeries. renewal of the brain parenchyma is restricted by many reasons such as inimical substances produced as the result of trauma and also inflammatory responses. a strong cascade of inflammatory responses begins as a result of tbi which include recalling peripheral leukocytes into the...

Despite pharmacological advances in the treatment of schizophrenia, significant number of patients continue to be treatment-resistant. Poor control of symptoms could be related to low concentration of antipsychotics because of non-adherence or pharmacokinetic issues. However, there is growing evidence that "true" treatment-resistance might be associated with biological changes, i.e. alterations...

Nutritional interventions are now recommended as strategies to delay Alzheimer's disease (AD) progression. The present study evaluated the neuroprotective effect (anti-inflammation) of lactic acid bacteria (either Lactobacillus fermentum LAB9 or L. casei LABPC) fermented cow's milk (CM) against lipopolysaccharide (LPS)-activated microglial BV2 cells in vitro. The ability of CM-LAB in attenuatin...

The role of neuroinflammation and the adaptive immune system in PD (Parkinson's disease) has been the subject of intense investigation in recent years, both in animal models of parkinsonism and in post-mortem PD brains. However, how these processes relate to and modulate α-syn (α-synuclein) pathology and microglia activation is still poorly understood. Specifically, how the peripheral immune sy...

Background: Alzheimer’s disease (AD), a progressive neuropsychiatric disorder, is characterized by neuroinflammation, β-amyloid plaques and neurofibrillary tangles. It has been demonstrated that systemic inflammation neuroinflammation caused lipopolysaccharide (LPS) injections in rodents leads to elevation Aβ levels neuronal cell death, finally resulting cognitive impairment.
 Methods: Ani...

neuroinflamation occurring after traumatic brain injury (tbi) is a complex phenomenon comprising distinct cellular and molecular events involving the injured cerebral tissue. mechanical injury to adult rat brain elucidated the accumulation in the affected area of trophic activity. in the tissue adjacent to the injury, trophic titers began to rise after the lesion. this study aimed to determine ...

Although anaesthesia is generally effective, safe and also an indispensable preoperative clinical approach, there is a really growing concern about usage, form of usage and dosage of it. Postoperative cognitive dysfunction (POCD) is one of the common postoperative complications that often affects elderly patients and includes a range of domains, may involve oxidative stress and neuroinflammatio...

1 7 6 7 jci.org Volume 125 Number 5 May 2015 Introduction Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder of motor neurons that begins focally and spreads, leading to weakness of limb, respiratory, and bulbar muscles. Immediately preceding death, there is a near total loss of limb and respiratory function, as well as a loss of the ability to chew, swallow, and speak. ALS is...