how to cite this article: tonekaboni sh, mollamohammadi m. neurodegeneration with brain iron accumulation: an overview. iran j child neurol. 2014 autumn;8(4): 1-8. abstract objective neurodegeneration with brain iron accumulation (nbia) is a group of neurodegenerative disorder with deposition of iron in the brain (mainly basal ganglia) leading to a progressive parkinsonism, spasticity, dystonia...

background: pantothenate kinase associated neurodegeneration (pkan) is the most prevalent type of neurodegeneration with brain iron accumulation (nbia) disorders characterized by extrapyramidal signs, and 'eye-of-the-tiger' on t2 brain magnetic resonance imaging (mri) characterized by hypointensity in globus pallidus and a hyperintensity in its core. all pkan patients have homozygous or compoun...

opDivision qf' Phauaacognosy, Department of' JdbdiclnaJ Resources, institute of Natural Medicine, Tbyama Medical and Pharmaceuticat University, 2630 Sugitani, Tbyama 930-OiP4, Jtu)an. bj21St Century COE Program, 7Q}'ama Mledical and Pharmaceuticat Uhivenylty, 2630 Sagitani, lb.Fama 930-OIV4, mpan. ofKampo Pharmaceutieal Sciences, Nihon Pharmaceutical University, 10281 Komuro, lna, Saitama 362-0...

Neurodegeneration with brain iron accumulation (NBIA) describes a group of progressive extrapyramidal disorders with radiographic evidence of focal iron accumulation in the brain, usually in the basal ganglia. Patients previously diagnosed with Hallervorden-Spatz syndrome fall into this category. Mutations in the PANK2 gene account for the majority of NBIA cases and cause an autosomal recessive...