in vitro culture systems using bone marrow cells from balb/c mice were set up in medium supplemented with spleen-derived medium. bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. the cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. some...

Background Endometriosis is a common gynecological disease, can cause severe pelvic pain. Studies demonstrated the presence of sensory nerve fibers in endometrium of endometriosis patient. Nevertheless, no information is available on mechanisms of sensory nerve formation in eutopic or ectopic lesions. Since HOX genes have important roles in both reproductive tract and nerve growth, we decided t...

The principle etiology of leg pain (sciatica) from lumbar disc herniation is mechanical compression of the nerve root. Sciatica is reduced by decompression of the herniated disc, i.e., removing mechanical compression of the nerve root. Decompression surgery typically reduces sciatica more than lumbar back pain (LBP). Decompression surgery reduces mechanical compression of the nerve root. Howeve...

Inflammation is portion of the body's immune response and it is basically a host protective response to tissue ischemia, injury, autoimmune responses or infectious agents. Although the information presented so far points to a detrimental role for inflammation in central nervous system (CNS) disease, it may also be useful. CNS demonstrates characteristic of inflammation, and in response to damag...

Background: Full-thickness burn injuries (FTBI) not only lead to a significant burden in multiple ways, including social life and self-esteem, but have also tremendous impact on environmental interaction by reducing sensibility manifold ways. On these grounds, possible ways solutions recover wounds are essentials should be overlooked. Methods: A review of experimental, clinical studies the rela...

Under normal conditions, the sympathetic neurotransmitter noradrenaline inhibits the production and release of pro-inflammatory cytokines. However, after peripheral nerve and tissue injury, pro-inflammatory cytokines appear to induce the expression of the alpha1A-adrenoceptor subtype on immune cells and perhaps also on other cells in the injured tissue. In turn, noradrenaline may act on up-regu...

breast cancer is common and is considered second cause of cancer related mortality in females. regarding importance of breast cancer, more investigation in this field is recommended. for many years investigators believed that neoplasms were not innervated but new findings have proved otherwise. this descriptive study was carried out to compare number of nerve fibers in benign, malignant and nor...

Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote ischemic preconditioning induces the local release of chemical mediators which activate the sensory nerve endings to convey signals to the brain. The...

INTRODUCTION Research on the mechanisms regulating tendon healing has predominantly focused on mechanical rather than biological features. Over the last decade, however, accumulating data suggests that besides cytokines and vascular factors also neuronal mediators are critical components of tissue repair. A variety of neuronal mediators, so called neuropeptides, have been identified and found t...

This article reviews the current knowledge of the biological aspects of dental tissue changes incident to orthodontic tooth movement. The inflammatory nature of these tissue changes was first recognized in the early 1970s, and since then a number of morphological and quantitative investigations have been published in support of this view. The studies dealing with vascular and cellular dental ti...