biglar permo-triassic bauxite deposit is located in ~15 km northwest of abgarm, southwest of ghazvin province, west of central iran. it consists of 8 stratiform and discontinuous bauxite lenses lying along the contact of ruteh (permian) and elika (triassic) carbonate formations. petrographically, the bauxite ores exhibit collomorphic-fluidal, pseudo-breccia, pseudo-porphyritic, panidio-morphic-...

biglar permo-triassic bauxite deposit is located in ~15 km northwest of abgarm, southwest of ghazvin province, west of central iran. it consists of 8 stratiform and discontinuous bauxite lenses lying along the contact of ruteh (permian) and elika (triassic) carbonate formations. petrographically, the bauxite ores exhibit collomorphic-fluidal, pseudo-breccia, pseudo-porphyritic, panidio-morphic-...

Insertions of Mutator transposons into maize genes can generate suppressible alleles. Mu suppression is when, in the absence of Mu activity, the phenotype of a mutant allele reverts to that of its progenitor. Here we present the characterization of five dominant Mu-suppressible alleles of the knox (knotted1-like homeobox) genes liguleless3 and rough sheath1, which exhibit neomorphic phenotypes ...

PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.

Mutations in an enzyme can result in a neomorphic catalytic activity in cancers. We applied cancer-associated mutations from isocitrate dehydrogenases to homologous residues in the active sites of homoisocitrate dehydrogenases to derive enzymes that catalyze the conversion of 2-oxoadipate to (R)-2-hydroxyadipate, a critical step for adipic acid production. Thus, we provide a prototypic example ...