purpose : to report an atypical case of acanthamoeba keratitis. patients & methods : a 19-year-old girl presented with a history of recurrent herpetic keratitis and a history of short-time contact lens wear. laboratory work-up for herpetic, bacterial, and acanthamoeba sources were negative and the patient failied to follow up. on later presentation she had corneal necrotizing stromal ulcer need...

purpose: to evaluate the effectiveness of corneal collagen cross-linking with uv-a and riboflavin (cxl) for treatment of refractory herpes simplex virus necrotizing keratitis. case reports: two patients with a diagnosis of hsv necrotizing stromal keratitis referred to khalili hospital eye emergency room and who were resistant to conventional treatment underwent cxl. response to treatment was ev...

Herpes simplex virus (HSV) necrotizing stromal keratitis is a common type of herpetic stromal keratitis (HSK). Antiviral medication alone cannot control the disease, and corticosteroid eye drops may aggravate the ulcer and result in corneal perforation. Amniotic membrane transplantation effectively treats superficial corneal ulcer resulting from necrotizing stromal HSK. However, the efficacy of...

OBJECTIVE To validate photographic bioimaging for evaluating the severity of herpes simplex virus keratitis. METHODS Stromal keratitis of patients in the Herpetic Eye Disease Study was clinically measured with a slitbeam micrometer and then photographed at trial entry. Calibrated images of 169 eyes were analyzed for the size, location, and density of stromal keratitis and endotheliitis, with ...

The authors have investigated the course of herpes simplex type 1 (HSV) keratitis in three different inbred strains of mice infected with four different HSV isolates. Severity of ocular disease and mortality is dependent upon both the virus isolate and the host strain. In particular, the likelihood of progression from self-limited dendritic keratitis to severe necrotizing stromal keratitis vari...

INTRODUCTION To evaluate the complications, efficacy of medical and surgical treatment, and outcome in patients with necrotizing scleritis and peripheral ulcerative keratitis associated with Wegener's granulomatosis. METHODS The authors reviewed a series of seven patients with Wegener's granulomatosis treated in the Corneal Department of Zhongshan Ophthalmic Center and the Department of Ophth...

PURPOSE Stromal herpes simplex virus keratitis (HSK) is an immune-mediated disease. Previous studies have indicated that T cells, neutrophils, and macrophages contribute to the tissue damage in HSK. It has been shown that human amniotic membrane promotes epithelial wound healing and has diverse anti-inflammatory effects. In this study, the effect of amniotic membrane transplantation (AMT) on co...

Ocular disease caused by herpes simplex virus (HSV) 1 ranges in severity from a self-limiting blepharitis, conjunctivitis, or dendritic keratitis to a disciform stromal edema and necrotizing stromal keratitis that can cause blindness. Herpes keratitis and stromal disease are distinct, readily differentiable clinical entities that can be studied in animal models. In pure dendritic herpes keratit...

Passive transfer of a monoclonal antibody (MAb) specific for glycoprotein D (gD) is highly effective in preventing the development of herpes simplex virus type 1-induced stromal keratitis. In the present study, we investigated whether animals which had been functionally depleted of T-cell subsets or asialo GM1+ cells would continue to be responsive to MAb therapy. BALB/c mice were depleted of C...