Neurotoxic lesions of nucleus basalis magnocellularis (NBM) in rats cause depletion of acetylcholine (ACh) in neocortex (Ncx) and deficits in passive avoidance (PA) behavior. Such deficits in behavior can be used to evaluate treatments designed to promote functional recovery. Because cultured astrocytes produce, store and release trophic factors known to enhance the rescue of damaged neurons, t...

AIM To investigate the primary electrophysiological and pharmacological properties of the nucleus basalis magnocellularis (nbM) neurons. METHODS Single unit extracellular recordings from the nbM neurons were obtained with glass micropipettes in urethane-anesthetized rats. RESULTS Most nbM neurons responded to noxious but not innocuous mechanical, thermal, chemical, and electrical stimuli. T...

HDAC inhibitors (HDACis) have been developed as promising anticancer agents in recent years. In this study, we synthesized and characterized a novel HDACi, termed NBM-HD-1. This agent was derived from the semisynthesis of propolin G, isolated from Taiwanese green propolis (TGP), and was shown to be a potent suppressor of tumor cell growth in human breast cancer cells (MCF-7 and MDA-MB-231) and ...

The nucleus basalis magnocellularis (nbm)-lesioned rat is considered to be a model of the cholinergic dysfunction observed in the cerebral cortices of Alzheimer's disease patients. The cholinergic markers, acetylcholine release and choline acetyltransferase activity, were decreased in the cerebral cortex of the nbm-lesioned rat. Kangenkaryu (KAN), a Chinese traditional medicine, is a typical pr...

BACKGROUND The tuberomammillary histaminergic neurons are involved in the sedative component of anesthetic action. The nucleus basalis magnocellularis (NBM) in the basal forebrain receives dense excitatory innervation from the tuberomammillary nucleus and is recognized as an important site of sleep-wake regulation. This study investigated whether NBM administration of histaminergic drugs may mo...

introduction: in the present study the effect of nucleus basalis of meynert (nbm) destruction on the temporal characteristics of response integration evoked by multiple whisker stimulations in rat barrel cortex was studied. material and methods: wistar male rats weighing 250-350 g were used. the animals were randomly distributed into two groups: in the first group bilateral nbm lesions was indu...

The effects on anatomy and behavior of a ribosomal inactivating protein (saporin) coupled to a monoclonal antibody against the low-affinity NGF receptor (NGFr) were examined. In adult rats, NGFr is expressed predominantly in cholinergic neurons of the medial septal area (MSA), diagonal band nuclei, and nucleus basalis magnocellularis (nBM), but also in noncholinergic cerebellar Purkinje cells. ...

The role of the nucleus basalis magnocellularis (NBM) in fear conditioning encoding is well established. In the present report, we investigate the involvement of the NBM histaminergic system in consolidating fear memories. The NBM was injected bilaterally with ligands of histaminergic receptors immediately after contextual fear conditioning. Histaminergic compounds, either alone or in combinati...

Acetylcholine in the brain has been associated with consciousness and general anesthesia effects. We tested the hypothesis that the integrity of the nucleus basalis magnocellularis (NBM) affects the response to general anesthetics. Cholinergic neurons in NBM were selectively lesioned by bilateral infusion of 192IgG-saporin in adult, male Long-Evans rats, and control rats were infused with salin...