introduction in spite of the increasing trend in opioid abusers worldwide, the prevalence of narcotic bowel syndrome (nbs) is undetermined. we aimed to estimate the prevalence of nbs and other opioid bowel dysfunction (obd) in opioid abusers in kerman, southeast iran. according to the best of our knowledge, this is the first study to assess the prevalence of nbs in opioid abusers. method by ref...

opioids are widely used for the treatment of malignant and non-malignant pains. these medications are accompanied by adverse effects, in particular gastrointestinal symptoms known as opioid bowel dysfunction (obd). the most common symptom of obd is refractory constipation that is usually stable regardless of the use of laxatives. narcotic bowel syndrome (nbs) is a subset of obd described as amb...

Patients with chronic abdominal pain without an organic basis present a difficult management problem. Some of these patients may be prescribed opiates initially which may result in requiring progressively higher doses for pain relief. In this clinical setting, the suspicion of narcotic bowel syndrome should be borne in mind. With appropriate treatment and counselling, further invasive investiga...

BACKGROUND Narcotic agents are frequently administered to manage increased intestinal motility in patients with short bowel syndrome, but long-term use is associated with gastrointestinal (GI) complaints. This analysis evaluated the incidence of narcotic use and abdominal adverse events among patients with short bowel syndrome receiving teduglutide. MATERIALS AND METHODS Pooled data from pati...

The worldwide use of opiates is increasing yet there is little evidence that in long-term, non-cancer patients, they have an efficacious effect on functional outcomes and quality of life measures. Although it seems paradoxical, chronic opiate use may lead to a pro-nociceptive state. Mechanisms for the development of the hyperalgesic state include activation of the opiate bimodal regulatory syst...

BACKGROUND Growing evidence demonstrates the adverse effects of narcotics in inflammatory bowel disease (IBD). We sought to study the relationship between narcotic use, objective measures of disease activity, and other associated factors in hospitalized patients with IBD. METHODS We performed a retrospective cohort study of all adult IBD patients admitted to a general medical or surgical ward...