The polyene antibiotic Amphotericin B (AMB) is one of the first therapeutic agents to be marketed commercially as nanosized formulations in which the drug is associated with lipids as liposomes or complexes. In this way, its renal toxicity is reduced and its therapeutic index improved. This review summarizes the particular properties of AMB which justify this type of formulation and the early w...

At the beginning of the second phase (Phase II) of the Frontier Materials Research Program in 1991, former Bioelectronic Materials activities were complemented by the Advanced Materials program and merged into the Laboratory for Exotic Nano-Materials. Since the initiation of Exotic Nano-Materials research, we have been committed to nanoscopic science and engineering, and unconventional combinat...

Fungal infections and leishmaniasis are an important cause of morbidity and mortality in immunocompromised patients. The macrolide polyene antibiotic amphotericin B (AmB) has long been recognized as a powerful fungicidal and leishmanicidal drug. A conventional intravenous dosage form of AmB, AmB- deoxycholate (Fungizone or D-AmB), is the most effective clinically available for treating fungal a...