نتایج جستجو برای: nanocurcumin

تعداد نتایج: 128  

Journal: :Molecular pharmaceutics 2013
Peng Zou Lawrence Helson Anirban Maitra Stephan T Stern Scott E McNeil

The objective of this study was to compare the pharmacokinetics and metabolism of polymeric nanoparticle-encapsulated (nanocurcumin) and solvent-solubilized curcumin formulations in Sprague-Dawley (SD) rats. Nanocurcumin is currently under development for cancer therapy. Since free, unencapsulated curcumin is rapidly metabolized and excreted in rats, upon intravenous (i.v.) administration of na...

2016
Abhishek Yadav Pramod Kushwaha

The present study is in continuation of our previous efforts to investigate the preventive efficacy of encapsulated curcumin nanoparticles (nanocurcumin) in mitigating effects of arsenic and/or fluoride. Curcumin was encapsulated in chitosan nanoparticles having a size distribution in the range of 50 nm. Sodium arsenite (2 mg/kg, orally) and Fluoride (50 ppm in drinking water) either alone or i...

2015
Sarita Nehra Varun Bhardwaj Lilly Ganju Deepika Saraswat Ferenc Gallyas

Hypoxia induced oxidative stress incurs pathophysiological changes in hypertrophied cardiomyocytes by promoting translocation of p53 to mitochondria. Here, we investigate the cardio-protective efficacy of nanocurcumin in protecting primary human ventricular cardiomyocytes (HVCM) from hypoxia induced damages. Hypoxia induced hypertrophy was confirmed by FITC-phenylalanine uptake assay, atrial na...

2013
Charitra N. Grama Palla Suryanarayana Madhoosudan A. Patil Ganugula Raghu Nagalla Balakrishna M. N. V. Ravi Kumar Geereddy Bhanuprakash Reddy

Curcumin, the active principle present in the yellow spice turmeric, has been shown to exhibit various pharmacological actions such as antioxidant, anti-inflammatory, antimicrobial, and anti-carcinogenic activities. Previously we have reported that dietary curcumin delays diabetes-induced cataract in rats. However, low peroral bioavailability is a major limiting factor for the success of clinic...

Journal: :Journal of Nanobiotechnology 2007
Savita Bisht Georg Feldmann Sheetal Soni Rajani Ravi Collins Karikar Amarnath Maitra Anirban Maitra

BACKGROUND Curcumin, a yellow polyphenol extracted from the rhizome of turmeric (Curcuma longa), has potent anti-cancer properties as demonstrated in a plethora of human cancer cell line and animal carcinogenesis models. Nevertheless, widespread clinical application of this relatively efficacious agent in cancer and other diseases has been limited due to poor aqueous solubility, and consequentl...

2016
F Katiraee J Ashrafai Helan SJ Emami Gh Hamidian E Babaei

BACKGROUND AND PURPOSE Use of curcumin, as a promising antifungal agent, is considered an alternative treatment for fungal infections; however, the low solubility of this agent limits its efficacy. Accordingly, in this study, we aimed to evaluate the in vitro and in vivo antifungal activities of dendrosomal nanocurcumin with improved solubility and bioavailability. MATERIALS AND METHODS The i...

2017
Firoozeh Niazvand Layasadat Khorsandi Mohammadreza Abbaspour Mahmoud Orazizadeh Negar Varaa Mahtab Maghzi Kheironesa Ahmadi

Curcumin has been found to be very efficacious against many different types of diseases. However, the major disadvantage associated with the use of curcumin is its low systemic bioavailability. In the present study the protective effects of curcumin-loaded poly lactic-co-glycolic acid nanoparticles (nanocurcumin) against mono-iodoacetate-induced osteoarthritis in rats was investigated. Mono-iod...

Journal: :Molecular pharmaceutics 2013
Hao Shen Xiaoyu Hu Magdalena Szymusiak Zaijie Jim Wang Ying Liu

We have formulated hydrophobic curcurmin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] into stable nanoparticle suspensions (nanocurcumin) to overcome its relatively low bioavailability, high rate of metabolism, and rapid elimination and clearance from the body. Employing the curcumin nanoformulations as the platform, we discovered that curcumin has the potential to alleviate m...

Journal: :Annals of military and health sciences research 2023

Background: Since EGFR inhibitors show a limited therapeutic effect on Glioblastoma multiforme patients, the EGFR/MAPK/STAT5/FN14 signaling pathway becomes vulnerable to invasive GBM cell population and may be suitable target for treatment of GBM. Nanocurcumin consumption exercise training are probably effective interventions in this pathway. Objectives: This study aimed investigate simultaneou...

2016
Mohammad Hossein Khosropanah Amin Dinarvand Afsaneh Nezhadhosseini Alireza Haghighi Sima Hashemi Fereidon Nirouzad Sepideh Khatamsaz Maliheh Entezari Mehrdad Hashemi Hossein Dehghani

Cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drug with low sid effects on immune system has developed as important area in new studies of immunopharmacology. Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer propertie...

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