نتایج جستجو برای: nanocarrier

تعداد نتایج: 1301  

2017
Fang Shan YuJuan Liu Haiying Jiang Fei Tong

Here, we describe a bone morphogenetic protein-2 (BMP-2) nanocarrier based on glycyrrhetinic acid (GA)-poly(ethylene glycol) (PEG)-b-poly(l-lysine) (PLL). A protein nanocarrier was synthesized, characterized and evaluated as a BMP-2 delivery system. The designed nanocarrier was synthesized based on the ring-opening polymerization of amino acid N-carboxyanhydride. The final product was measured ...

2016
Karolina A. Walker Jean-François Stumbé Rainer Haag

A water-soluble, core-multishell (CMS) nanocarrier based on a new hyperbranched polyester core building block was synthesized and characterized towards drug transport and degradation of the nanocarrier. The hydrophobic drug dexamethasone was encapsulated and the enzyme-mediated biodegradability was investigated by NMR spectroscopy. The new CMS nanocarrier can transport one molecule of dexametha...

Journal: :ACS nano 2010
Hoon-Sung Cho Zhongyun Dong Giovanni M Pauletti Jiaming Zhang Hong Xu Hongchen Gu Lumin Wang Rodney C Ewing Christopher Huth Feng Wang Donglu Shi

For early cancer diagnosis and treatment, a nanocarrier system is designed and developed with key components uniquely structured at nanoscale according to medical requirements. For imaging, quantum dots with emissions in the near-infrared range (∼800 nm) are conjugated onto the surface of a nanocomposite consisting of a spherical polystyrene matrix (∼150 nm) and the internally embedded, high fr...

Journal: :Biomaterials 2009
Simi Gunaseelan Shahriar Pooyan Peiming Chen Mahta Samizadeh Matthew S Palombo Stanley Stein Xiaoping Zhang Patrick J Sinko

In the current study, the design, synthetic feasibility and biochemical characterization of biodegradable peptidic PEG-based nanocarriers are described. The components were selected to influence the body elimination pathway upon nanocarrier biodegradation. Two prototypical nanocarriers were prepared using non-PEGylated and PEGylated peptidic cores [CH(3)CO-(Lys-betaAla-betaAla)(X)-Cys-CONH(2) (...

Journal: :Chemical communications 2016
Hongxin Tong Jianwei Du Huan Li Qiao Jin Youxiang Wang Jian Ji

A programmed supramolecular nanocarrier was developed for multistage targeted photodynamic therapy. This smart nanocarrier exhibited enhanced cellular uptake and controlled mitochondria targeting, as well as an excellent photodynamic therapeutic effect after light irradiation.

2014
Emanuel Fleige Rahul Tyagi Rainer Haag

CMS, core-multishell; NR, Nile red; MTX, methotrexate; mPEG, methoxypoly(ethylene glycol); PG, polyglycerol; dPG, dendritic polyglycerol; PEG, poly(ethylene glycol); CMS-mPEG, coremultishell nanocarrier with a mPEG outer shell; EPR, enhanced permeation and retention; PG[G1], polyglycerol dendron of generation 1; PG[G2], polyglycerol dendron of generation 2; CMS-G1, core-multishell nanocarrier w...

2011
Mahesh L. Patil Min Zhang Tamara Minko

A novel triblock poly(amido amine)-poly(ethylene glycol)-poly-l-lysine (PAMAM-PEG-PLL) nanocarrier was designed, synthesized, and evaluated for the delivery of siRNA. The design of the nanocarrier is unique and provides a solution to most of the common problems associated with the delivery and therapeutic applications of siRNA. Every component in the triblock nanocarrier plays a significant rol...

2014
Yu Shao Changying Shi Gaofei Xu DanDan Guo Juntao Luo

To develop a feasible and efficient nanocarrier for potential clinical application, a series of photo and redox dual responsive reversibly cross-linked micelles have been developed for the targeted anticancer drug delivery. The nanocarrier can be cross-linked efficiently via a clean, efficient, and controllable coumarin photodimerization within the nanocarrier, which simplify the formulation pr...

Journal: :Journal of applied biomaterials & biomechanics : JABB 2009
Stefano Pietronave Michele Iafisco Deborah Locarno Lia Rimondini Maria Maria Prat

Recent developments in nanotechnology have provided new tools for both cancer imaging and treatment. The functionalization of the nanocarrier based drugs using biological ligands allows increasing specificity of drug targeting enhancing efficacy and reducing side effects. In this paper some current nanocarrier based drugs are described and the principles for their functionalization in cancer tr...

Journal: :nanomedicine journal 0
asia majidi department of nanobiotechnology, tarbiat modares university, tehran, iranسازمان اصلی تایید شده: دانشگاه تربیت مدرس (tarbiat modares university) maryam nikkhah department of nanobiotechnology, tarbiat modares university, tehran, iranسازمان اصلی تایید شده: دانشگاه تربیت مدرس (tarbiat modares university) saman hosseinkhani department of nanobiotechnology, tarbiat modares university, tehran, iranسازمان اصلی تایید شده: دانشگاه تربیت مدرس (tarbiat modares university) sadeghian faranak

objective(s): the introduction of nucleic acids into cells for therapeutic objectives is significantly hindered by the size and charge of these molecules and therefore requires efficient vectors that assist cellular uptake. for several years great efforts have been devoted to the study of development of recombinant vectors based on biological domains with potential applications in gene therapy....

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید