A novel bone-targeted delivery systems based on nanocapsules was developed utilizing a Zeolitic Imidazolate Framework (ZIF-8) as a template and catechol-modified gelatin as wall material. A targeting ligand was facilely conjugated on the surface of nanocapsules. Simvastatin was encapsulated within the nanocapsules with a loading of 37.9%. Hydroxyapatite binding and in vivo biodistribution of th...

Hollow mesoporous-SiO2 nanocapsules have been synthesized at room temperature using unmodified cowpea Mosaic Virus (CPMV) as a template, and without using any catalyst or surfactant during the synthesis. The average size of the capsules synthesized was ∼200-250 nm with a 60-100 nm hollow core. The resulting nanocapsules were characterized using high resolution transmission electron microscopy (...

We developed a novel method to prepare nanocapsules. A solute often crystallizes when its solubility alters from one solvent to another, and its firstborn crystals are used as templates to prepare nanocapsules for the first time, which is called firstborn microcrystallization method. By using this method, the maximum diameter of the nanocapsules including artesunate is about 76 nm, and wrapping...

The microwave absorption properties of Ni/(C, silicides) nanocapsules prepared by an arc discharge method have been studied. The composition and the microstructure of the Ni/(C, silicides) nanocapsules were determined by means of X-ray diffraction, X-ray photoelectric spectroscopy, and transmission electron microscope observations. Silicides, in the forms of SiOx and SiC, mainly exist in the sh...

This paper describes characterization of lyophilized lipid nanocapsules loaded with Alexa 488 by fluorescence correlation spectroscopy (FCS). Fluorimetry analysis of nanocapsules containing self-quenching concentrations of 5- and 6-carboxyfluorescein was performed to establish a point of reference for FCS. FCS results complemented the results obtained by fluorimetry for a bulk nanocapsule solut...

BACKGROUND The aim of this study was to design and evaluate hybrid cyclodextrin (CD) nanocapsules intended for the oral delivery of the anticancer agent camptothecin (CPT) in order to maintain drug stability in the body and to improve its eventual bioavailability. For this reason, an amphiphilic cyclodextrin (CD) derivative per-modified on the primary face 6OCAPRO was used as core molecule to f...

This study evaluated the potential of poly(iso-butyl cyanoacrylate) (PBCA) nanocapsules dispersed in a biocompatible microemulsion to facilitate the absorption of insulin following intragastric administration to diabetic rats. Insulin-loaded PBCA nanocapsules were prepared in-situ in a biocompatible water-in-oil microemulsion by interfacial polymerisation. The microemulsion consisted of a mixtu...

The binding behavior of guests (dyes and DNA) into peptide nanocapsules formed via self-assembly of a 24-mer b-annulus peptide fragment obtained from the capsid protein of the tomato bushy stunt virus is reported. The pH dependence of the f potential of the peptide nanocapsules indicates that the Cand N-termini are directed to the exterior and interior of the nanocapsules, respectively. Equilib...

Nanocapsule suspensions containing coenzyme Q10 were prepared by interfacial deposition. The nanocapsules showed characteristics compatible with dermal application: slightly acid pH, drug content close to 100%, particle size between 213 and 248 nm with low polydispersity and negative zeta potential. Three cosmetic formulations for skin application were developed, one with the free-coenzyme Q10,...

The synthesis of novel fluorescent materials represents a very important step to obtain labeled nanoformulations in order to evaluate their biological behavior. The strategy of conjugating a fluorescent dye with triacylglycerol allows that either particles differing regarding supramolecular structure, i.e., nanoemulsions, nanocapsules, lipid-core nanocapsules, or surface charge, i.e., cationic ...