Nanoparticle surface chemistry is known to play a crucial role in interactions with cells and their related cytotoxic effects. As inhalation is a major route of exposure to nanoparticles, we studied specific uptake and damages of well-characterized fluorescent 50 nm polystyrene (PS) nanobeads harboring different functionalized surfaces (non-functionalized, carboxylated and aminated) on pulmonar...

nanobiotechnology appears to be an emerging science which leads to new developments in the field of medicine. importance of the magnetic nanomaterials in biomedical science cannot be overlooked. the most commonly used chemical methods to synthesize drugable magnetic nanobeads are co-precipitation, thermal decomposition and microemulsion. however monodispersion, selection of an appropriate coati...

Nanobiotechnology appears to be an emerging science which leads to new developments in the field of medicine. Importance of the magnetic nanomaterials in biomedical science cannot be overlooked. The most commonly used chemical methods to synthesize drugable magnetic nanobeads are co-precipitation, thermal decomposition and microemulsion. However monodispersion, selection of an appropriate coati...

In this paper, CdTe quantum dot (QD)@silica nanobeads were used as modulated photoluminescence (PL) sensors for the sensing of ascorbic acid in aqueous solution for the first time. The sensor was developed based on the different quenching effects of Fe(2+) and Fe(3+) on the PL intensity of the CdTe QD@ silica nanobeads. Firstly, the PL intensity of the CdTe QDs was quenched in the presence of F...

The selective sorting of Pb ions in bloodstream flow has been carried out via mixed chitosan nano-beads aqua-solution and then selectively sponge up the Pb ions by a chelating mechanism. To obtain an efficient chelating reaction and a chelating nanobead that can be attracted and separated from the bloodstream flow, a microfluidic component of a microchannel with electrodes has been designed and...

A fast solid-phase microextraction method using core-shell ZnO-poly (methyl methacrylate) nanobeads (ZnO-PMMA) as adsorbent was established. This fast method with high enriching efficiency and salt tolerance capability depends on the structure of the core-shell nanobeads. First, the large surface area of the PMMA shell makes the dispersive nanobeads capture samples quickly, by virtue of multi-i...

Campylobacter jejuni causes 2.1 to 2.4 million cases of foodborne illnesses in the United States each year with some of the cases linked to eating undercooked poultry or handling raw poultry and poultry products. Thus, a rapid, specific method is needed to detect C. jejuni on poultry and poultry products. The objective of this research was to develop a sensitive immunoassay method for rapid det...

A novel drug delivery vehicle that specifically targets using ultrasound radiation force (USRF) and biotin-avidin interactions is presented. Model vehicles consist of avidinated fluorescent nanobeads bound directly to the biotinylated lipid shells of preformed microbubbles. USRF was used to deflect the vehicle from the center of flow to a tube surface in order to facilitate receptor-ligand medi...

As the lung is one of the main routes of exposure to manufactured nanoparticles, we developed an in vitro model resembling the alveolo-capillary barrier for the study of nanoparticle translocation. In order to provide a relevant and ethical in vitro model, cost effective and easy-to-implement human cell lines were used. Pulmonary epithelial cells (Calu-3 cell line) and macrophages (THP-1 differ...