By comparing differential gene expression in the insulin-like growth factor (IGF)-IR null cell fibroblast cell line (R- cells) with cells overexpressing the IGF-IR (R+ cells), we identified the Mystique gene expressed as alternatively spliced variants. The human homologue of Mystique is located on chromosome 8p21.2 and encodes a PDZ LIM domain protein (PDLIM2). GFP-Mystique was colocalized at c...

This article, the result of a research project presented as a Master’s degree dissertation in the graduate program of “Teaching of Health Education” at UNIFESP, seeks to highlight the pertinence of analyzing epilepsy and especially, the paradoxical experience of the epileptic individual through literary narrative. Using as its object the novel, The Idiot, by Fyodor Dostoyevsky, it seeks to disc...

le fou d'elsa de louis aragon porte de manière de plus ou moins visible la trace et la mémoire d’un héritage littéraire considérable. c'est une création originale à partir de la coexistence d’éléments distincts mais compatibles, qui relèvent de toutes sortes d’influences, d’imprégnations, de réminiscences[1]. c’est un enchevêtrement d’emprunts à la littérature arabe, à l'histoire andalouse du x...

Over fifty years ago Arthur Eddington wrote [1]: " The second law of thermodynamics holds, I think, the supreme position among the laws of Nature. If someone points out to you that your pet theory of the universe is in disagreement with Maxwell's equations – then so much the worse for Maxwell's equations. If it is found to be contradicted by observation, well, these experimentalists do bungle t...

position effect variegation (in which the probability of Epigenetic effects have often enough been viewed as inactivation of a gene translocated to a position near verging on the mystical. It is a paradox of conventional heterochromatin decreases with its distance from hetgenetics that two alleles can have the same genetic erochromatin). One of the characteristics of a state that sequence but s...

The evolution of clinical transplantation has hinged on 2 seminal turning points. The first was the demonstration in 1953 by Billingham, Brent, and Medawar that chimerism-associated tolerance could be induced deliberately in neonatal mice by infusing adult donor hematolymphopoietic cells. This discovery escalated in a straight line over the next 15 years to successful bone marrow transplantatio...