Infantile myofibromatosis is a rare fibrous tumor of infancy. The cutaneous solitary type has typically an excellent prognosis. However, histologically, it is important to rule out leiomyosarcoma, which has a poor prognosis. The low frequency of mitosis was definitive for a diagnosis of infantile myofibromatosis. We present a cutaneous solitary-type case of infantile myofibromatosis. Following ...

Myofibroma is a solitary benign tumor of myofibroblasts. Myofibromatosis describes multiple, simultaneous myofibromas at different sites in various organs. Myofibromatosis is a rare but well recognized entity which was originally thought to affect only neonates and infants. It is now apparent however that adults may also be affected. Solitary cases affecting the oral cavity appear to be rare. T...

BACKGROUND Infantile myofibromatosis is a rare mesenchymal disorder of infancy that can extensively involve the viscera including the gastrointestinal tract. CASE PRESENTATION In this report, an exceptional case of infantile myofibromatosis is described in which rectal prolapse and sigmoid colo-colonic intussusception were the initial presentations of colorectal involvement in a 2-month-old p...

Infantile myofibromatosis (IM) is the most common fibrous tumor of infancy. IM may arise in a solitary or multicentric form, with similar histopathological findings, however, the clinical features and prognoses may vary. The solitary form tends to occur predominantly in males and is typically observed in the dermis, subcutis or deep soft tissues. The reported incidence of solitary osseous myofi...

Infantile myofibromatosis is a mesenchymal disorder characterized by the fibrous proliferation of the skin, bone, muscle and viscera. It is the most common fibrous tumor in childhood. We present a newborn with skin and bone disease without visceral involvement, who showed good response to vinblastine and methotrexate. Clinical features, etiology, diagnosis, and treatment are reviewed.

Infantile myofibromatosis is a rare mesenchymal disorder of early childhood characterized by the formation of tumors in skin, muscle, viscera, bone, and subcutaneous tissue [1-3]. It may present with a solitary form or a multi-centric form. The condition was previously known as congenital generalized myofibromatosis. It affects almost exclusively infants and young children. It was felt to be a ...

Received March 29, 2003 Abstract Congenital infantile myofibromatosis is a rare disorder with multiple fibromatous tumours in skin, bone, muscle, viscera and subcutaneous tissue presenting in early infancy. Multiple lytic bone lesions and vertebra involvement are also common, mimicking the clinical picture of metastatic tumours. However, it is a disease with variable prognosis depending on the ...