a 41 year old woman was referred to our center because of a left breast mass lesion of about two months duration. routine pathologic examination of the mass revealed a .neoplastic tissue composed of large ovoid cells with clear cytoplasm arranged in broad sheets that were separated by thin bundles of connective tissue. immunohistochemically tumor cells express smooth muscle actin, cytokeratin, ...

Abstract Myoepithelial carcinoma is a morphologically diverse tumor which either arises de novo or from the malignant transformation of its benign counterpart i.e. myoepithelioma. These are relatively lesser known entities and rarely found in head neck region. Although rare, their first presentation usually painless growing mass as seen our case well infamous for lymph node recurrence distant m...

Epithelial myoepithelial carcinoma is a rare biphasic low grade neoplasm of salivary glands; it most commonly occurs in the parotid gland but can also arise in minor salivary glands. Here a case of 58-year-old female presented with left cheek swelling of one-year duration. CT scan revealed a localized submandibular salivary gland tumor mass not involving surrounding tissues. Histological examin...

Background: Myoepithelial carcinoma, also called malignant myoepithelioma, is a relatively rare malignant tumor that occurs most frequently in the salivary glands. A few isolated cases have been described in other locations, including the lung, bronchus, oral cavity, nasopharynx and larynx. The region of cavernous sinus is an uncommon condition of involvement in myoepithelial carcinoma. To the ...

Epithelial-myoepithelial carcinoma (EMC) is considered as a rare malignant salivary gland neoplasm with good prognosis, low recurrence rate and rare metastasis. Here we present a case of epithelial-myoepithelial carcinoma in a 42-year-old female with a swelling of 3-year duration in her palate. Histopathologic evaluation of the lesion demonstrated a well-circumscribed, biphasic salivary gland t...

epithelial myoepithelial carcinoma is a rare biphasic low grade neoplasm of salivary glands; it most commonly occurs in the parotid gland but can also arise in minor salivary glands. here a case of 58-year-old female presented with left cheek swelling of one-year duration. ct scan revealed a localized submandibular salivary gland tumor mass not involving surrounding tissues. histological examin...

TGF-beta-stimulated clone-22 (TSC-22) was reported to be a differentiation-inducing factor which negatively regulates the growth of salivary gland cancer cells. In the present study, we examined the expression of TSC-22 in salivary gland tumors by immunohistochemistry. In pleomorphic adenoma (PA), most of the sparse myoepithelial-like tumor cells, which are considered as the differentiated cell...

Our recent studies revealed that focal alterations in breast myoepithelial cell layers significantly impact the biological presentation of associated epithelial cells. As pregnancy-associated breast cancer (PABC) has a significantly more aggressive clinical course and mortality rate than other forms of breast malignancies, our current study compared tumor suppressor expression in myoepithelial ...

OBJECTIVES The aim of this study was to present a rare neoplasm, Primary myoepithelial carcinoma arising from the palate, and to review its diagnostic criteria, pathologic and clinical characteristics, treatment options and prognosis. CLINICAL PRESENTATION AND INTERVENTION Myoepitheliomas are tumors arising from myoepithelial cells mainly or exclusively. Myoepitheliomas mostly occur in saliva...

Myoepithelial cells have been implicated in the regulation of the transition from in situ to invasive neoplasia in salivary gland tumors. Considering the importance of the microenvironment of the tumor, the present in vitro study therefore analyzed the morphological and phenotypic changes undergone by benign myoepithelial cells from pleomorphic adenoma (PA) stimulated by tumor-conditioned mediu...