Two patients are documented, one with a cerebral infarct and one with a primary brain tumor, both of whom initially had a normal electrocardiogram but subsequently developed the classic pattern of transmural anteroseptal myocardial infarction; however, in both cases the autopsy proved the electrocardiograph pattern to be related to "focal myocytolysis" of the myocardium. Both patients also exhi...

BACKGROUND Pulmonary embolism (PE) is a significant cause of morbidity and mortality. In a recent study in patients with PE, an increased level of macrophages was found in the right ventricle. OBJECTIVE To evaluate the presence of inflammatory cells, myocytolysis and intracavitary thrombi in the left and right ventricle of patients who died because of PE as a putative new source of heart fail...

Fulminant myocarditis (FM) represents a crucial cardiac pathology with extensive hemodynamic compromise occurring in a previously healthy patient. Early death occurs because of acute cardiac decompensation from inflammation, necrosis, and myocytolysis. Nevertheless, in this situation implantation of an extracorporeal circulatory support system may ensure cardiac recovery. We herein report our e...

OBJECTIVE Patients with ischemic heart failure may benefit from coronary artery bypass grafting. The histopathological variables associated with improvement in ejection fraction 6 months after surgery were assessed. METHODS This study comprised 24 patients indicated for coronary artery bypass grafting, ejection fraction < 35%, functional class II-IV heart failure, and mean age 59 +/- 9 years....

Aim: Endomyocardial biopsies form the golden standard in diagnosing (borderline) lymphocytic myocarditis ((B)LM) in living patients. Herein immunohistochemistry (IH) is mandatory. Diagnosing (B)-LM in autopsy hearts however is less defined. In this study we performed immunohistochemical stainings of heart slides in a cohort of consecutive adult autopsies that were evaluated subsequently with th...

Although the role of angiotensin II (Ang II) in the pathogenesis and progression of the failing heart is uncertain, previous reports have suggested that myocyte injury may be a component in this process. In this study, we investigated this possibility in more detail. Cardiotoxic effects of nonacutely hypertensive doses of Ang II were examined in 90 rats, including those receiving an angiotensin...

objective(s): carbon nanotubes have unique mechanical, electrical, and thermal properties, with potential different applications in nanomedicine, electronics, and other industries. these new applications of carbon nanotubes in different industries lead to the increased exposure risk of nanomaterials to human. up to now, all aspects of carbon nanotubes toxicity are not completely clear following...

The histologic criteria for determining the age of a myocardial infarct were established by Mallory et al in 1939. The present study was undertaken to reexamine more quantitatively the evolution of myocardial infarction and to determine the prevalence of two recently described pathologic findings: wavy fibers and myocytolysis. The medical records of 1,155 patients dying of myocardial infarction...

Fuchsinophilic myocardial degeneration is described in 12 per cent of I69 patients dying of strokes, head injuries, brain tumours, and intracranial infection. This may have resulted from excessive secretion of catecholamines, after sympathetic stimulation, and three possible methods of preventing such damage are suggested. There is no evidence fro;n a study of the incidence of subendocardial ha...