نتایج جستجو برای: myelodysplastic syndromes
تعداد نتایج: 86513 فیلتر نتایج به سال:
background: myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. patients and methods: we compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome an...
Results Vγ9Vδ2 T cells, the major circulating γδ T-cell subset, were reduced in myelodysplastic syndromes, but mainly in myelodysplastic syndromes’ patients with associated autoimmune diseases, suggesting that this anomaly was largely due to the autoimmune component. On the other hand, bromohalohydrin pyrophosphate-induced expansion of the Vγ9Vδ2 T-cell population in all 15 control samples, but...
Myelodysplastic syndromes (MDS) are a heterogeneous group of neoplastic diseases the hematopoietic cells manifested by ineffective hematopoiesis and tendency to transform into acute myeloid leukemia. MDS should be considered in differential diagnosis cytopenia, especially elderly. This article presents recommendations experts Polish Adult Leukemia Group (PALG) for myelodysplastic syndromes. We ...
BACKGROUND Myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders with a high propensity to transform into acute myeloid leukemia. Heterozygous missense mutations in IDH1 at position R132 and in IDH2 at positions R140 and R172 have recently been reported in acute myeloid leukemia. However, little is known about the incidence and prognostic impact of IDH1 and ID...
Introduction: Myelodysplastic syndrome is a pathology characterized by its hematopoietic, pluripotential ineffective process in the bone marrow, i.e. causing dysplasia at least one of hematopoietic lines with functional and morphological alterations, which, some point may evolve into leukemia. Objective: review, analyze describe most notable features myelodysplastic syndromes. Methodology: A to...
Flow cytometric analysis is a recommended tool in the diagnosis of myelodysplastic syndromes. Current flow cytometric approaches evaluate the (im)mature myelo-/monocytic lineage with a median sensitivity and specificity of ~71% and ~93%, respectively. We hypothesized that the addition of erythroid lineage analysis could increase the sensitivity of flow cytometry. Hereto, we validated the analys...
Etiology of myelodysplastic syndromes The models for the development of sporadic MDS suggest the role of cumulative environmental exposures in genetically predisposed individuals. There is increasing evidence for a complex genetic predisposition to MDS involving naturally occurring DNA polymorphisms in genes that mediate DNA repair and metabolize environmental carcinogens.3 Large epidemiologic ...
The myelodysplastic syndromes are a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more cell lineages and increased risk of evolution to acute myeloid leukemia (AML). Recent advances in immunophenotyping of hematopoietic progenitor and maturing cells in dysplastic bone marrow point to a useful role for multiparameter flow cytometry (FCM) in t...
Myelodysplastic syndromes (MDS) comprise a heterogeneous group of malignant hematopoietic stem cell disorders that are characterized by ineffective blood production and variable risk transformation into acute myeloid leukemia. In recent years, significant progress in MDS biological research has allowed the addition new drugs to few existing therapeutic options. This article presents recommendat...
Reducing the Need for HLA-Matched Platelet Transfusion Some patients with acute leukemia or myelodysplastic syndromes thrombocytopenia may become resistant to random donor transfusions of plat...
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