نتایج جستجو برای: myelin basic protein mbp

تعداد نتایج: 1492153  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس 1388

مقدمه: ام اس (ms) بیماری دمیلینه کننده التهابی مزمن سیستم عصبی است که با واسطه فعال شدن سیستم ایمنی پدید می آید. امروزه آنتی اکسیدانهایی همچون ویتامین های eو d3 در بیماریهای تحلیل برنده سیستم عصبی مورد استفاده قرار می گیرند، هرچند که مکانیسم عمل دقیق آنها به خوبی مشخص نیست. در این مطالعه اثر تجویز ویتامین های eو d3 بر میزان دمیلیناسیون و مرگ سلولی، تکثیر، تمایز و مهاجرت سلول های بنیادی عصبی و ر...

Journal: :iranian red crescent medical journal 0
samiie pouragahi department of molecular medicine, school of medicine, qazvin university of medical sciences, qazvin, iran; multiple sclerosis research center, sina hospital, department of neurology, tehran university of medical sciences, tehran, iran; department of molecular genetics, national institute of genetic engineering and biotechnology (nigeb), tehran, iran marjan nassiri-asl cellular and molecular research center, department of pharmacology, school of medicine, qazvin university of medical sciences, qazvin, iran; cellular and molecular research center, department of pharmacology, school of medicine, qazvin university of medical sciences, qazvin, iran. tel: +98-2833336001, fax: + 98-2833324971 mohammad ali sahraian multiple sclerosis research center, sina hospital, department of neurology, tehran university of medical sciences, tehran, iran mehdi sadeghi department of bioinformatics, national institute of genetic engineering and biotechnology (nigeb), tehran, iran abdolali banki department of neurology, baqiyatallah university of medical sciences, baqiyatallah hospital, tehran, iran zahra zamanzadeh national institute of genetic engineering and biotechnology (nigeb), tehran, iran

conclusions molecular assays in the early stages of the disease could help in elucidating the effectiveness of the mbp as a prognostic factor in ms. methods this study is convergence of three arms including in silico and in vitro (bioinformatics) with the in vivo (experimental). a novel methodology combining molecular techniques was used to confirm the antigenic properties of mbp and study its ...

Journal: :BMJ 2021

Myelination was studied in aggregating cell cultures derived from mechanically 15- to 16-day fetal rat brains. Myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) were localized immunocytochemically 20-micrometers-thick Vibratome 1-micrometer- thick Epon sections at 15, 20, 25, 30 days vitro. The occurrence of these proteins correlated with the ultrastructural appearance oligode...

Journal: :Developmental neuroscience 1999
P Montague D Kirkham A S McCallion R W Davies P G Kennedy M Klugmann K Nave I R Griffiths

Myelin-associated oligodendrocytic basic protein (MOBP) and myelin basic protein (MBP) share many structural similarities. MOBP is synthesised by mature oligodendrocytes and localised at the major dense line (MDL), suggesting a role in the myelin compaction process. The shiverer mouse, a deletion mutant of the myelin basic protein (Mbp) gene, has poorly compacted myelin with essentially no MDL....

E KEYHANI, F MOKHTARI, S RAFEIE,

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system of presumed autoimmune etiology. One of the best animal models of demyelinating diseases is experimental autoimmune encephalomyelitis (EAE), which can be induced in a variety of animals by injection of a target antigen such as myelin basic protein (MBP). The immune responses against the target amino acids caus...

Journal: :medical journal of islamic republic of iran 0
f mokhtari from the center of researches for biology and microbiology, institute of standard and industrial research of iran, karaj, s rafeie thedepartment of immunology, school of medicine, tehran university of medical sciences,tehran e keyhani the institute of biochemistry and biophysics, tehran university, tehran, i.r. iran.

multiple sclerosis (ms) is an inflammatory disease of the central nervous system of presumed autoimmune etiology. one of the best animal models of demyelinating diseases is experimental autoimmune encephalomyelitis (eae), which can be induced in a variety of animals by injection of a target antigen such as myelin basic protein (mbp). the immune responses against the target amino acids cause tis...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1993
P M Mathisen S Pease J Garvey L Hood C Readhead

We have identified a myelin basic protein (MBP) isoform in mouse embryos that includes an exon upstream of the usual transcription initiation site. This isoform, embryonic-neonatal MBP (E-MBP), is expressed at the protein level in the embryonic nervous system at a time when other MBP isoforms are not detected. In addition to the central and peripheral nervous systems of the embryo and neonate, ...

Objective: Multiple sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As myelin basic protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 health...

فرجی , مهدیه , مشایخی , فرهاد , موسوی بنه حور, سیده زهرا ,

Background and purpose: Oligodendrocytes are responsible for myelin synthesis in the central nervous system (CNS). Olig1 and Olig2 play an important role in regulating the development of oligodendrocyte precursor cells (OLPs). Myelin basic protein (MBP) is the main component of myelin sheath. Leukemia inhibitory factor (LIF) has an important role in myelination and pathology of multiple scleros...

Journal: :Biophysical journal 2016
Olena Steshenko Débora M Andrade Alf Honigmann Veronika Mueller Falk Schneider Erdinc Sezgin Stefan W Hell Mikael Simons Christian Eggeling

Myelin is a multilayered membrane that ensheathes axonal fibers in the vertebrate nervous system, allowing fast propagation of nerve action potentials. It contains densely packed lipids, lacks an actin-based cytocortex, and requires myelin basic protein (MBP) as its major structural component. This protein is the basic constituent of the proteinaceous meshwork that is localized between adjacent...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید