the term mitral valve prolapse (mvp) is used for a particular subset of patients with hyperadrenergic dysautonomia. it occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. the adenylate cyclase activity in mvp dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 normal su...

The term mitral valve prolapse (MVP) is used for a particular subset of patients with hyperadrenergic dysautonomia. It occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. The adenylate cyclase activity in MVP dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 norma...

Emerging studies have demonstrated that major vault protein (MVP) may play critical roles in tumor development and progression. However, the biology functions of MVP in breast cancer have not yet been evaluated. The present study is to investigate the expression level and the significance of MVP in breast cancer and to explore the mechanism underlying the deregulation of MVP. We examined the ex...

BACKGROUND Knowledge of mitral valve prolapse (MVP) inheritance is based on pedigree observation and M-mode echocardiography. The extent of familial clustering of MVP among unselected individuals in the community using current, more specific echocardiographic criteria is unknown. In addition, the importance of nondiagnostic MVP morphologies (NDMs; first described in large pedigrees) has not bee...

BACKGROUND Mitral regurgitation (MR) due to mitral valve prolapse (MVP) is often treatable by surgical repair. However, the very long-term (>10-year) durability of repair in both anterior leaflet prolapse (AL-MVP) and posterior leaflet prolapse (PL-MVP) is unknown. METHODS AND RESULTS In 917 patients (aged 65+/-13 years, 68% male), surgical correction of severe isolated MR due to MVP (679 rep...

Major vault protein (MVP) is the main constituent of the vault ribonucleoprotein particle and is identical to lung resistance-related protein (LRP). Although MVP is also expressed in several types of normal tissues, little is known about its physiological role. In the present study, we identified the crucial MVP promoter elements that regulate MVP expression. An examination of tissue expression...

Echocardiography has been accepted as the diagnostic modality of choice for mitral valve prolapse (MVP). The determine the effect of position on echocardiographic diagnosis of MVP, we examined 693 consecutive patients referred to the echocardiography laboratory because of suspected MVP. First, patients were examined using the usual standard M-Mode echocardiography( left parasternal third or fou...

To determine mitral valve and extravalvular findings associated with mitral valve prolapse (MVP) in patients with the Marfan syndrome, we compared mitral leaflet and anular dimensions and motion by computerized two-dimensional echocardiography in 53 Marfan patients (28 with M-mode echocardiographic MVP) to those in 48 adults with primary MVP and in 35 normal subjects. Mitral leaflet billowing o...

BACKGROUND Heart rate variability (HRV) has been shown to be a useful measure of autonomic activity in healthy and mitral valve prolapsed (MVP) subjects. However, the effects of posture and gender on HRV in symptomatic MVP and normal adults had not been elucidated in Taiwan. METHODS A total of 118 MVP patients (7 males, 39 ± 7 years old; and 111 females, 42 ± 13 years old) and 148 healthy con...