A multisystem disease is one that usually affects a number of organs and tissues during the course of the illness (Dorland, 2008). It has long been observed that some individuals with schizophrenia have levels of general physical illnesses in excess of that seen in the general population, but recent studies suggest that most people with schizophrenia have comorbid physical disease and multiple ...

mitochondrial disorders (mids) may occasionaly go along with dysmorphism but hand deformities, as in the following case, have been only rarely reported. a 72 year old female with ptosis, hypoacusis, tremor, myopathy, diabetes mellitus, arterial hypertension, severe cardiac disease, pulmonary hypertension, gastric carcinoid, hepatopathy, generalised atherosclerosis, anemia, polyarthrosis, and hy...

AN AI~A~S'rHESIOLOCIST is aware of the need for caution when confronted with a patient suffering from a myotonic syndrome. On reviewing the literature, 1,2 it becomes evident that the stress has been on the myotonic aspects of the disease. However, dystrophia myotonica is a multisystem disease, and the following case report and related discussion illustrate the many facets which need considerat...

langerhans cell histiocytosis (lch) is a rare disorder described as three different entities including eosinophilic granulomaof bone, the hand-schuller-christian syndrome, and letterer-siwe disease. lch is currently classified into singlesystem lch, and multisystem lch. patients with single system lch have an excellent prognosis, and are mostlytreated with local therapy. multisystem lch is subd...

Langerhans cell histiocytosis (LCH) is a rare disorder described as three different entities including eosinophilic granulomaof bone, the Hand-Schuller-Christian syndrome, and Letterer-Siwe disease. LCH is currently classified into singlesystem LCH, and multisystem LCH. Patients with single system LCH have an excellent prognosis, and are mostlytreated with local therapy. Multisystem LCH is subd...

Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most comm...