coexisting ankylosing spondylitis and hereditary multiple exostoses have rarely been reported (three patients) previously. a 27-year-old man with hereditary multiple exostoses is presented as a fourth report. at the age of 15 years, the patient had multiple exostoses around the knee, ankle and shoulder joints. he was diagnosed with ankylosing spondylitis 3 years ago. the patient’s sister and hi...

a seven year-old boy with several painless masses on the ribs and shoulder was referred to our hospital. the masses were so prominent that they prevented the child’s sleep. since the patient had been ridiculed by his friends due to the rib prominences, he had refused to attend school. after clinical and radiological evaluations, the masses were diagnosed as hereditary multiple exostoses of the ...

Hereditary multiple exostosis is an intriguing genetic condition with a clinical impact in the field of orthopaedics, paediatrics and oncology. In this review we highlight the current knowledge about this condition from a clinical and scientific point of view. This gives us more insight into the molecular mechanisms and current models on which therapeutic agents are based. It allows for a multi...