several transporters appear to be important in transporting various drugs. many patients, who receive morphine as analgesic medication, also receive other medications with potency of changing morphine transport by affecting p-glycoprotein (p-gp) and oatp2 transport system. this could influence morphine pharmacokinetics and pharmacodynamics. the aim of present study was to elucidate the transpor...

multidrug resistance (mdr) is a complex phenomenon in which many different genes regulating drug transport, cellular repair, detoxification and drug metabolism are involved. nevertheless, in most drug resistant cell lines and cancer patients up-regulation of abc-transporter genes such as mdr associated protein (mrp1) gene could be at the basis of the drug resistance phenotype. we aimed to decre...

Fifty-two canine and eighteen feline primary pulmonary carcinomas were evaluated immunohistochemically for the expression of proteins associated with multidrug resistance to anti-cancer drugs. P-glycoprotein (PGP), multidrug resistance-related protein (MRP) and lung resistance-related protein (LRP) expression were frequently observed in neoplastic cells of all carcinoma types, and metallothione...

Abstract Proton electrochemical gradient-driven multidrug efflux activity of representatives the major facilitator superfamily (MFS) secondary active transporters contributes to antimicrobial resistance pathogenic bacteria. Integral mechanism these is a proposed competition between substrate and protons for binding site protein. The current work investigated Escherichia coli MFS multidrug/H + a...

Resistance to cytotoxic drugs remains a major obstacle for the successful treatment of cancer (1). Over the past two decades, a great deal of information has emerged that elucidates how cancer cells become drug resistant. At least one prominent drugresistance mechanism in cancer cells is the reduction of intracellular drug concentration at the putative drug target. There are at least two mechan...

BACKGROUND Lung resistance-related protein (LRP), like multidrug resistance gene 1 (MDR1) and multidrug resistance-associated proteins (MRP), has been associated with intrinsic therapeutic resistance in various malignancies. To date, there has been no study on the expression of LRP in urothelial carcinomas of the renal pelvis and ureter. We investigated the protein and mRNA expression levels of...

objective(s): acquisition of tnf-α resistance plays role in the onset and growth of malignant tumors. previous studies have demonstrated that mcf-7 cell line and its doxorubicin resistant variant mcf-7/adr are resistant against the cytotoxic effects of tnf-α. in this study, we investigated the role of akt activation in resistance of mcf-7 and mcf-7/adr against tnf-α cytotoxicity. materials and ...