نتایج جستجو برای: multidrug resistance 1 gene
تعداد نتایج: 3830621 فیلتر نتایج به سال:
background: for the first time we tested an association between the human multidrug resistance gene 1 (mdr1) polymorphisms (snps) and idiopathic pulmonary fibrosis (ipf). several mdr1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. materials and methods: we genotyped three mdr1 polymorphisms of 48 ipf patients and 100 control subj...
conclusions adeabc efflux system plays a vital role in multidrug resistance in clinical a. baumannii isolates. it was noted that the most important gene responsible for multidrug resistance within this system was the adeb gene especially in carbapenems resistance. methods this study was conducted on 84 multidrug resistant and 13 carbapenem-susceptible a. baumannii isolates obtained from burn an...
Abstract Background: Efflux systems are components of the bacterial membrane that play a role in homeostasis of the cell and extrusion of toxic compounds. Efflux pumps of the resistance nodulation cell division (RND) superfamily, confer multidrug resistance to their host when over-expressed. One of the RND efflux systems, is AdeABC which have been characterized for A. baumannii. Another pump be...
multidrug resistance (mdr) is a complex phenomenon in which many different genes regulating drug transport, cellular repair, detoxification and drug metabolism are involved. nevertheless, in most drug resistant cell lines and cancer patients up-regulation of abc-transporter genes such as mdr associated protein (mrp1) gene could be at the basis of the drug resistance phenotype. we aimed to decre...
OBJECTIVES Conflicting data from studies on the potential role of multidrug resistance 1 gene polymorphisms in inflammatory bowel disease may result from the analysis of genetically and geographically distinct populations. Here, we investigated whether multidrug resistance 1 gene polymorphisms are associated with inflammatory bowel diseases in patients from Rio de Janeiro. METHODS We analyzed...
conclusions this study demonstrated the co-existence of rmtc and blandm-1 genes for the first time in turkey. the spread of this resistant type should be monitored and limited through molecular surveillance. results twenty k. pneumoniae strains showed resistance to amikacin, and 40 were resistant to gentamicin. the mic value was found to be > 512 µg/ml in five amikacin-resistant strains and > 1...
conclusions the result of this study showed a high prevalence of class 1 integron gene in most p. aeruginosa strains isolated from different parts of the environment and equipment used in icu. the role of these transferable genetic agents has been proven in the creation of resistance. so, the environmental bacteria represent a reservoir for dissemination of clinically relevant multidrug-resista...
Multidrug resistance is a phenomenon that cancer cells develop a cross-resistant phenotype against several unrelated drugs, and permeability glycoprotein derived from the overexpression of multidrug resistance gene 1 has been taken as the most significant cause of multidrug resistance. In the present study, ginsenoside Rh2 was used to reverse permeability glycoprotein-mediated multidrug resista...
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