background: one of the limitations in the treatment of common diseases such as cancer chemotherapy is development of multidrug re sistance (mdr). polymorphisms could alter the expression level of mdr1 gene, which plays an important role in mdr. in this research, the frequency of c3435t, c1236t, and g2677t/a polymorphisms of mdr1 gene was investigated in a large group of population from hamadan ...

background: chemotherapy plays a very important role in the treatment of leukemia but the resistance properties of the lymphoblasts limit the effect of chemotherapy. one of the main mechanisms of resistance to chemotherapy is the increased expression of mdr1 gene. the aim of this study was to explore the effect of resveratrol on the expression of mdr1 gene in leukemic lymphoblast of new cases o...

conclusions this study represented an increasing rate of mdr p. aeruginosa in burn and wound samples. efflux mexab genes were detected in all mdr and pdr strains. the p. aeruginosa strain isolated from burn cases showed higher drug resistance and pdr resistance was only noted in a burn sample. materials and methods one-hundred and fifty p. aeruginosa were isolated from burn and wound infections...

conclusions methicillin resistance is a specialized concern in clinical studies, and it is mandatory to detect this mechanism by an accurate method that is updated periodically. increasing the resistance of s. aureus to multiple antibiotics underlines the need for intermittent resistance surveillance. results methicillin resistance was detected in 38% of s. aureus isolates, confirmed by the aga...

salmonella enterica is recognized as one of the major food-borne pathogens with more than 2,500 serotypesworldwide. the present study addresses antimicrobial resistance of salmonella enterica serovar enteritidisisolates in iran. a collection of 151 salmonella spp. isolates collected from poultry were serotyped toidentify salmonella enteritidis. sixty-one salmonella enteritidis were subsequently...

the emergence of multi-drug resistant strains of pseudomonas aeruginosa has complicated treatment decision and may lead to treatment failures. in this study, we describe the trends of drug-resistant p. aeruginosa isolated in blood cultures from patients detected in a tertiary teaching hospital and evaluated the prevalence of resistance to amikacin, ampicillin, carbeni- cillin, cefixime, cefotax...

background : multi drug-resistant mycobacterium tuberculosis (mdr-tb) is an infection with a causative bacillus which is resistant to at least two drugs, isoniazid and rifampin. the purpose of this study is to evaluate the prevalence of tb resistance to first-line drugs of newly diagnosed active pulmonary tuberculosis. methods : this cross-sectional study was performed on 77 patients with newly...

objective: global surveillance has shown that drug resistant (dr) tuberculosis (tb) is widespread. prompt detection of mycobacterium tuberculosis drug resistance is essential for effective control of tb. the most frequent mutations associated with isoniazid (inh) resistance in mycobacterium are substitutions at codons 315 in the katg gene and the maba-inha promoter region (−15). this survey eva...

antibiotic resistance of pseudomonas aeruginosa remains a major problem in burn patients. the main objective of this study was to determine the antibiotic resistance pattern and frequency of class 1 integrons among p. aeruginosa strains isolated from patients with burn wound infections in a new burn centre in guilan, iran.the bacterial isolates were collected from 182 patients with burn wound i...

background: the frequency of the multi-drug resistance 1 (mdr1) gene c3435t polymorphism differs in various ethnical populations such as asian, african, and caucasians populations. a silent c3435t polymorphism in exon 26 of mdr1 has been reported to be associated with a decreased expression of p-gp in tt genotypes carriers compared with cc genotypes carriers. materials and methods: to evaluate ...