OBJECTIVE To assess the use of trans, trans-muconic acid as a biomarker of occupational exposure to benzene. METHODS Trans, trans-muconic acid in urine samples of exposed (exposed group, n=36) and non-exposed (non-exposed group, n=116) workers to benzene. Urinary levels of trans, trans-muconic acid were quantified by high-performance liquid chromatography. The study sample consisted of subjec...

1. An enzyme for the cycloisomerization of 2- and 3-chloro-cis,cis-muconic acid was isolated from 3-chlorobenzoate-grown cells of Pseudomonas sp. B13. It was named muconate cycloisomerase II, because it could it clearly be differentiated by its Km and Vmax. values from an ordinary muconate cycloisomerase, which functioned in benzoate catabolism and exhibited low activity with the chlorinated su...

The present work concerns with an investigation on the solubility of cis,cis-muconic acid dissolution in different polar solvents by characterizing and modeling the dissolution as a function of temperature. Water, ethanol, 2-propanol and acetic acid have been investigated as solvents in the range temperatures from a 298.15 to 348.15 K. Owing to the absence of cis,cis-muconic acid solubility...

A limited life cycle assessment (LCA) was performed on a combined biological and chemical process for the production of adipic acid, which was compared to the traditional petrochemical process. The LCA comprises the biological conversion of the aromatic feedstocks benzoic acid, impure aromatics, toluene, or phenol from lignin to cis, cis-muconic acid, which is subsequently converted to adipic a...

7. It is concluded that tran8-tran8-muconic acid is probably a true metabolite of benzene and is not produced in vivo from the ci8-ci8-acid. It is suggested that the 68-c68-acid need not be an intermediate in the formation of the tran8-tranm-acid in the animal body. The expense of this work was in part defrayed by a grant from the Medical Research Council. We are grateful to Prof. R. Cruickshan...

Muconic acid has gained interest as a bio-based platform chemical to produce value-added compounds including adipic and terephthalic acid. In this study, fermentation strategy based on in situ product recovery was established boost process performance counteract inhibition. An optimized reactive extraction mixture for muconic developed consisting of 12.5% (v/v) CYTOP 503 canola oil showing high...

JAFF, [1909] isolated muconic acid from the urine of rabbits and dogs to which benzene had been administered. The amount was approximately 03% of the benzene given, but Jaff6 considered that a larger amount was formed in the tissues, possibly as much as 25-30%, by the opening of the benzene ring, because he found that injected muconic acid was metabolized, only about 1% being recovered in the u...

background: for its toxicity, benzene exposure is one of the main health concerns for high risk occupations like gasoline station workers. however, there is little knowledge about the effect of benzene metabolites on hematological parameters. objective: to evaluate the correlation between the urinary level of trans, trans-muconic acid (t, t-ma), a benzene metabolite, and some hematological para...

Natural and anthropogenic emissions of aromatic hydrocarbons from biomass burning, agro-industrial settings, and fossil fuel combustion contribute precursors to secondary aerosol formation (SOA). How these compounds are processed under humid tropospheric conditions is the focus of current attention to understand their environmental fate. This work shows how catechol thin films, a model for oxyg...