Objective: The Losartan potassium mucoadhesive buccal tablet were prepared using mucoadhesive polymers such as Carbopol 940P, pectin, sodium CMC, Sodium alginate, HPMC K4M, HPMC K15M and HPMC K100M in alone and in combination as release retarding agent to prolong the drug release and to avoid first pass metabolism. Methods: The mucoadhesive buccal tablets were prepared by direct compression met...

mucoadhesive drug delivery systems were developed to sustain drug delivery via various mucus membranes for either local or systemic delivery of poorly absorbed drugs such as peptides and proteins as well as drugs that are subjected to high first-pass metabolism. the present study was undertaken to use isolated calendula mucilage as a mucoadhesive agent and to formulate controlled release buccoa...

Omeprazole pellets containing mucoadhesive tablets were developed by direct punch method. Three mucoadhesive polymers namely hydroxypropylemethylcellulose K4M, sodium carboxy methylcellulose, carbopol-934P and ethyl cellulose were used for preparation of tablets which intended for prolong action may be due to the attachment with intestinal mucosa for relief from active duodenal ulcer. Mucoadhes...

In this work, the dissolution-absorption studies were conducted on marketed tablets of acyclovir (ACIVIR-200mg) and the mucoadhesive tablets of acyclovir using varying concentration of sodium lauryl sulfate as a permeation enhancer. The purpose of this study was to improve the absorption of acyclovir using sodium lauryl sulfate as permeation enhancer. The everted and perfused intestine model wa...

In present study, mucoadhesive vaginal tablet of sertaconazole was designed using a combination of mucoadhesive polymers like Carbopol 934P, chitosan, carboxymethylcellulose sodium, sodium alginate, methyl cellulose, hydroxypropyl methylcellulose and hydroxypropyl cellulose. Effervescent was incorporated into formulations to enhance swellabilty of mucoadhesive tablet. For various drug-free form...

The study is related to the formulation and evaluation of mucoadhesive buccal tablets Anastrozole enhance its bioavailability by avoiding 1st pass effect. succeeded in developing containing two layers (mucoadhesive backing layer) a design that permits unidirectional release drug. Tablets were prepared double direct compression method using (carbopol 934) as primary polymer, Sod.alginate, Na CMC...

Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...

the purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. a 32 full factorial design was employed to study the effect of independent variables like carbopol-934p and hydroxypropyl methylcellulose k100m, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...

background the dilution and rapid elimination of topically applied drugs due to the flushing action of saliva is a major difficulty in the effort to eradicate infections of oral cavity. utilization a proper delivery system for incorporation of drugs has a major impact on drug delivery and such a system should be formulated for prolonged drug retention in oral cavity. objectives the aim of the p...

The aim of study was to prepare and characterize mucoadhesive buccal tablets of glipizide using different Mucoadhesive polymers such as Carbopol 940, Sodium alginate and HPMC K15M in combination. Twenty one formulation were developed with different concentration of mucoadhesive polymers in each formulation.The formulated buccal tablets were tested for surface pH,in vitro drug release and moistu...