نتایج جستجو برای: msi

تعداد نتایج: 3019  

Journal: :iranian journal of public health 0
mr abbaszadegan division of human genetics, immunology research center, avicenna research institute, mashhad univers h asadzadeh aghdayi internal medicine ward, razavi hospital, mashhad, iran f rastin dept. of obstetrics & gynecology, imam reza hospital, mums, mashhad, iran e dadkhah division of human genetics, immunology research center, avicenna research institute, mashhad univers m lotfalizadeh n mohamadian roshan

background: this study was designed to determine the frequency of microsatellite instability (msi) in young iranian pa­tients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease. methods : microsatellite status was analyzed in 23 patients with endometrioid type endometrial cancer who were less than 55 years. clinicopathologic characte...

2004
Timothy M. Pawlik Chandrajit P. Raut Miguel A. Rodriguez-Bigas

Microsatellite instability (MSI) is a well-recognized phenomenon that is classically a feature of tumors in the hereditary non-polyposis colorectal syndrome. Ten to 15% of sporadic colorectal cancers, however, will have MSI. Microsatellite unstable tumors can be divided into two distinct MSI phenotypes: MSI-high (MSI-H) and MSI-low (MSI-L). MSI sporadic colorectal cancers with a high level of M...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
J M Michael-Robinson L E Reid D M Purdie A E Biemer-Hüttmann M D Walsh N Pandeya L A Simms J P Young B A Leggett J R Jass G L Radford-Smith

Sporadic colorectal cancer (CRC) characterized by high-level DNA microsatellite instability (MSI-H) has a favorable prognosis. The reason for this MSI-H survival advantage is not known. The aim of this study was to correlate proliferation, apoptosis, and prognosis in CRC stratified by MSI status. The proliferative index (PI) was measured by immunohistochemical staining with the Ki-67 antibody i...

Journal: :Cancer research 2003
Yuriko Mori Florin M Selaru Fumiaki Sato Jing Yin Lisa A Simms Yan Xu Andreea Olaru Elena Deacu Suna Wang Jennifer M Taylor Joanne Young Barbara Leggett Jeremy R Jass John M Abraham David Shibata Stephen J Meltzer

Frequent microsatellite instability MSI (MSI-H) occurring in human tumors is characterized by defective DNA mismatch repair and unique clinical features. However, infrequent MSI (MSI-L) has not been attributable to any other defined molecular pathway, and its existence as a biologically distinct category has been challenged. Moreover, the global molecular phenotypes (GMPs) underlying MSI-H, MSI...

2004
C M Wright O F Dent R C Newland M Barker P H Chapuis E L Bokey J P Young B A Leggett J R Jass G A Macdonald

Background: Colorectal cancers (CRCs) may be categorised according to the degree of microsatellite instability (MSI) exhibited, as MSI-high (MSI-H), MSI-low (MSI-L), or microsatellite stable (MSS). MSI-H status confers a survival advantage to patients with sporadic CRC. Aims: To determine if low levels of MSI are related to the clinicopathological features and prognosis of sporadic stage C CRC....

2003
Yuriko Mori Florin M. Selaru Fumiaki Sato Jing Yin Lisa A. Simms Yan Xu Andreea Olaru Elena Deacu Suna Wang Jennifer M. Taylor Joanne Young Barbara Leggett Jeremy R. Jass John M. Abraham David Shibata Stephen J. Meltzer

Frequent microsatellite instability MSI (MSI-H) occurring in human tumors is characterized by defective DNA mismatch repair and unique clinical features. However, infrequent MSI (MSI-L) has not been attributable to any other defined molecular pathway, and its existence as a biologically distinct category has been challenged. Moreover, the global molecular phenotypes (GMPs) underlying MSI-H, MSI...

Journal: :International journal of clinical and experimental medicine 2015
Bing Li Hong-Yi Liu Shao-Hua Guo Peng Sun Fang-Ming Gong Bao-Qing Jia

OBJECTIVE To investigate whether microsatellite instability (MSI) of gastric cancer and precancerous lesions were existed and its effect. METHODS Laser microdissection was used. Gastric, intestinal metaplasia, dysplasia and normal mucosa were collected respectively. Five microsatellite loci were selected and MSI was detected by denaturing high-performance liquid chromatography. RESULTS In t...

2006
Toshiaki Watanabe Takashi Kobunai Etsuko Toda Yoko Yamamoto Takamitsu Kanazawa Yoshihiro Kazama Junichiro Tanaka Toshiaki Tanaka Yoshihiro Okayama Yoshikazu Sugimoto Toshinori Oka Shin Sasaki Tetsuichiro Muto Hirokazu Nagawa

Promoter methylation of the mismatch repair gene plays a key role in sporadic microsatellite instability (MSI) colorectal cancers. However, promoter methylation often occurs in proximal colon cancers, and molecular phenotypes underlying MSI cancers in distal colon have not been fully clarified. Our goal was to clarify the difference between MSI and microsatellite stability (MSS) cancers and, fu...

Journal: :Cancer research 2006
Toshiaki Watanabe Takashi Kobunai Etsuko Toda Yoko Yamamoto Takamitsu Kanazawa Yoshihiro Kazama Junichiro Tanaka Toshiaki Tanaka Tsuyosi Konishi Yoshihiro Okayama Yoshikazu Sugimoto Toshinori Oka Shin Sasaki Tetsuichiro Muto Hirokazu Nagawa

Promoter methylation of the mismatch repair gene plays a key role in sporadic microsatellite instability (MSI) colorectal cancers. However, promoter methylation often occurs in proximal colon cancers, and molecular phenotypes underlying MSI cancers in distal colon have not been fully clarified. Our goal was to clarify the difference between MSI and microsatellite stability (MSS) cancers and, fu...

2008
Bo-Sung Yoon Young-Tae Kim Jae-Hoon Kim Sang-Wun Kim Eun-Ji Nam Nam-Hoon Cho Jae-Wook Kim Sunghoon Kim

PURPOSE We evaluated the expression of microsatellite instability (MSI) in sporadic ovarian tumors using 5 standard and 9 new MSI markers to determine the clinical significance of MSI in sporadic epithelial ovarian tumors. MATERIALS AND METHODS MSI was examined in 21 borderline and 25 malignant ovarian tumors. Polymerase chain reaction (PCR) was performed using the 5 markers recommended by th...

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