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a 36-year-old woman, diagnosed with systemic lupus erythematosus (sle), showed bulbar symptoms including impaired memory, slurred speech and swallowing difficulty 7 days before admission. magnetic resonance imaging (mri) showed symmetric confluent hyperintensities in the bilateral cerebral white matter on t2 weighted imaging (t2-wi), extended into the genu of the internal capsule and the crus c...

We describe how proton MR spectroscopy ((1)H-MR spectroscopy) was useful in elucidating the diagnosis of galactosemia in an undiagnosed 6-month-old infant. In vivo (1)H-MR spectroscopy of the brain showed a doublet at 3.7 parts per million, which was identified as galactitol (Gal-ol) by in vitro (1)H-MR spectroscopy of the urine. Galactosemia was subsequently confirmed by laboratory tests and t...

MR spectroscopy is used to provide in vivo biochemical information about cerebral metabolites. Magnetic field homogeneity secondary to anatomic interfaces, hemorrhage, or necrosis may lead to suboptimal MR spectroscopy. Susceptibility-weighted imaging (SWI) can identify field inhomogeneity and could be used to guide MR spectroscopy voxel placement, leading to higher-quality MR spectroscopy exam...

Magnetic resonance (MR) spectroscopy has received little attention from the clinical radiology community. Indeed, most MR spectroscopic studies are performed by a small and dedicated group of individuals, mostly basic scientists. This behavior is partly because MR spectroscopy does not produce “pictures” but results in “graphs,” and until lately, it could only be obtained with dedicated units a...

SUMMARY: MR spectroscopy allows insight into the chemical composition of human tissue noninvasively. Thereby it can help to better characterize pathologic processes affecting the spinal cord andmay provide important clinicalmarkers for differential diagnosis. However, due to technical challenges, it has been rarely applied to the spinal cord. The aim of this review was to summarize the technica...

PURPOSE We compared the metabolic information obtained from single-voxel proton MR spectroscopy and positron emission tomography (PET) in patients with temporal lobe epilepsy. METHODS Twenty-nine patients with temporal lobe epilepsy were screened for metabolic abnormalities with both proton MR spectroscopy and PET. Lateralization with MR spectroscopy was possible by using NAA/(Cho+Cr) and an ...

BACKGROUND AND PURPOSE Magnetic resonance (MR) spectroscopy can be used to determine the side of seizure onset in patients with temporal lobe epilepsy. Some patients with abnormal MR spectroscopy findings also have contralateral abnormalities, which in some cases have been reported to normalize after temporal lobe resection. With the aim of better understanding the mechanisms underlying abnorma...