Objective(s) While the nucleus accumbens and the striatum have received much attention regarding their roles in stereotyped behaviors, the role of the medial prefrontal cortex (mPFC) has not been investigated to the same degree. Few studies have reported the role of the mPFC in dopaminergic induction of locomotor hyperactivity. The mPFC is a heterogeneous area (the anterior cingulated, prelimbi...

objective(s) while the nucleus accumbens and the striatum have received much attention regarding their roles in stereotyped behaviors, the role of the medial prefrontal cortex (mpfc) has not been investigated to the same degree. few studies have reported the role of the mpfc in dopaminergic induction of locomotor hyperactivity. the mpfc is a heterogeneous area (the anterior cingulated, prelimbi...

Objective(s): Many studies have focused on ventral tegmental area than of other mesocorticolimbic areas, and implicated a key role for the medial prefrontal cortex (mPFC) in the development of addictive behaviors. So far, the role of gamma-aminobutyric acid (GABA) receptors in the discriminative properties of morphine has received little attention and few studies evaluated the role of these rec...

objective(s): drug addiction is one of the fastest growing social problems that researchers, for many years, have been trying to find proper strategies for its prevention and treatment. short-term physical activity is considered as acceptable for the treatment and prevention of addiction. on the other hand, prefrontal cortex is known to be responsible for many of the complex behavioral response...

Abstract Social hierarchy greatly influences behavior and health. Both human animal studies have signaled the medial prefrontal cortex (mPFC) as specifically related to social hierarchy. Dopamine D1 receptors (D1Rs) D2 (D2Rs) are abundantly expressed in mPFC, modulating its functions. However, it is unclear how DR-expressing neurons mPFC regulate Here, using a confrontation tube test, we found ...

Abstract The medial prefrontal cortex (mPFC) steers goal-directed actions and withholds inappropriate behavior. Dorsal ventral mPFC (dmPFC/vmPFC) circuits have distinct roles in cognitive control, but underlying mechanisms are poorly understood. Here we use neuroanatomical tracing techniques, vitro electrophysiology, chemogenetics fiber photometry rats engaged a 5-choice serial reaction time ta...

The ability to change behavioural strategies in the face of a changing world has been linked to the integrity of medial prefrontal cortex (mPFC) function in several species. While recording studies have found that mPFC representations reflect the strategy being used, lesion studies suggest that mPFC is necessary for changing strategy. Here we examine the relationship between representational ch...

Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivation. Previously institutionalized youths, who experienced early maternal depriv...

nterest in the medial prefrontal cortex (mPFC) as a source of behavioral inhibition has increased with the mounting evidence for a unctional role of the mPFC in extinction of conditioned fear. In fear extinction, a tone-conditioned stimulus (CS) previously paired ith a footshock is presented repeatedly in the absence of footshock, causing fear responses to diminish. Here, we review converging v...

The ventral hippocampus (VH) may have an important role in spatial memory processes and emotional behaviors through connections with the medial prefrontal cortex (mPFC) and amygdala. Although the mPFC and amygdala receive afferent projections from the VH, it has not been determined whether the individual VH neurons project to both the mPFC and the amygdala. In this study, antidromic responses t...