the objective of the present study was to prepare controlled release formulation of moxifloxacin hydrochloride ocular nanoparticles. the nanoparticles were prepared by solvent displacement method using eudragit rl 100 as a polymer. different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. the formulations were evaluated i...

Moxifloxacin Hydrochloride is a fluorinated quinolone antibacterial and Bromfenac Sodium is a non-steroidal anti-inflammatory. The combination formulation is used for the treatment of the reduction of post operative inflammatory conditions of the eye. Three new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Mox...

A simple HPTLC method having high accuracy, precision and reproducibility was developed for the routine estimation of moxifloxacin hydrochloride in the tablets available in market and was validated for various parameters according to ICH guidelines. moxifloxacin hydrochloride was estimated at 292 nm by densitometry using Silica gel 60 F254 as stationary phase and a premix of methylene chloride:...

Moxifloxacin hydrochloride ophthalmic solution 0.5% (Vigamox((R))) is the ocular formulation/adaptation of moxifloxacin. Moxifloxacin is a broad spectrum 8-methoxyfluoroquinolone which terminates bacterial growth by binding to DNA gyrase (topoisomerase II) and topoisomerase IV, essential bacterial enzymes involved in the replication, translation, repair and recombination of deoxyribonucleic aci...

A straightforward, sensitive, and quick spectrophotometric approach was created validated for the detection of Ciprofloxacin hydrochloride, Moxifloxacin Roxithromycin hydrochloride in pure form. These techniques were based upon fact that these antibiotics produced dark yellow ion pairs when combined with bromophenol blue. The binary complex universal buffer solution optimum pH values demonstrat...

This work describes five simple, specific and accurate spectrophotometric methods which developed and validated for determination of moxifloxacin hydrochloride in presence of its acidic degradation product without previous separation, namely; bivariate, graphical absorbance ratio, area under the curve, simultaneous equation and dual wavelength. Calibration graphs were established in the range o...

Two simple and rapid spectrophotometric methods were developed for the determination of two binary mixtures: moxifloxacin hydrochloride (MFH) with ketorolac tromethamine (KTM) and ciprofloxacin hydrochloride (CFH) with dexamethasone sodium phosphate (DSP). The first method, zero-crossing derivative spectrophotometry, depends on measuring the second derivative peak and trough values at 304 nm an...

The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated i...

Electrochemical behaviour of fluoroquinolone Antibiotic drug, moxifloxacin hydrochloride has been studied in aqueous medium using DC polarography and cyclic voltammetry. Moxifloxacin exhibits single well-defined cathodic peak in all the buffers like acetate buffer, phosphate buffer and B.R.buffer. The characteristics of the peak have been examined at different concentrations, pH and scan rates....