background: lead is an industrial heavy metal that can decrease sperm motility. objective: the aim was to investigate the protective effects of calcium against lead on motility of spermatozoa. materials and methods: in total 40 adult male swiss white mice were randomly divided into 5 groups (control, lead of 1st wk, lead of 2nd wk, lead/calcium of 1st wk and lead/calcium of 2nd wk). the lead gr...

background: pentoxifylline (px) prevents camp breakdown by inhibiting the activity of the camp-phosphatase and presumably, stimulates sperm motion. incubation with px causes hyperactivation of sperm, an important step in achieving fertilization, and leads to changes in membranes associated with sperm capacitation. objective: the purpose of this study was to examine the effects of pentoxifylline...

background: curcumin has shown to affect sperm motility and function in vitro and fertility in vivo. the molecular mechanism(s) by which curcumin affects sperm motility has not been delineated. since modulation of intracellular ph (phi) and plasma membrane polarization is involved in sperm motility, the present study was conducted to investigate the effect of curcumin on these sperm (human and ...

objective: to determine bilateral effects of unilateral iatrogenic vas deferens trauma (uit) on epididymal sperm characteristics and in vitro fertilizing capacity in an experimental mouse model. methods: experiments were performed on three equal groups each comprising six adult male mice. following anaesthesia, uit was induced by clamping left vas deferens with a mosquito clamp in fully locked ...

this study was aimed to assess the protective effects of cornus mas fruit extract (cmfe) and vitamin e (vit e) on sperm quality parameters in the methotrexate (mtx)-treated mice. forty-eight young adult male mice (8-12 weeks) were randomly divided into six groups including control and test groups. the control group received normal saline orally , and the test groups were treated mtx (20 mg kg-1...

Background: Sports, hypothermia and hyperthermia as some stressors inhibit male reproductive functions and are associated with subfertility or infertility. We investigated whether water temperature and chronic swimming are effective on mouse sperm parameters. Materials and Methods: Adult male mouse(N=35) were randomly divided into 7 groups: 1-controls 2-cold water (100C) with swimming 3- cold w...

the aim of this study was to evaluate changes that occur in motility parameters of progesterone treated mouse spermatozoa during course of hyperactivation. mouse spermatozoa treated with different doses of progesterone were videotaped after 10 min and 90 min of incubation. for each sperm, one second of movement of the head-midpiece junction was traced from the videotape and for each tracing sev...

background: various approaches have been used in the attempts to improve the quality of frozen–thawed mouse sperms. according to literatures, it seems that hyaluronic acid (ha) has an important role on the permeability and motility of sperms and their interaction with gametes. objective: for evaluation of ha supplementation on sperm characteristics and fertilization capability, we investigated ...

Background: The study of specific genes expressed in the testis is important to understanding testis development and function. Spermatogenesis is an attractive model for the study of gene expression during germ cell differentiation. Spermatogenesis associated-19 (Spata-19) is a recently-identified important spermatogenesis-related gene specifically expressed in testis. Its protein product is in...

The purpose of this study was to evaluate the efficiency of intracytoplasmic sperm injection (ICSI) and Piezo-assisted sperm injection after pretreatment with calcium ionophore (CaI) on the mouse embryo development. Methods: In this study, the conventional ICSI and Piezo-ICSI procedures were used. The efficacy of the methods was examined after mouse matured oocytes were fertilized with or witho...