neospora caninum (n. caninum) is an apicomplexan parasite and causes abortion and congenital neosporosis in cattle worldwide. in this study, we evaluate the virulence of a n. caninum isolate on mouse strain c57bl/6. six groups of five mice c57bl/6 were intraperitoneally inoculated with 1 × l07, 1.5 × l07, 2 × l07, 3 × l07 and 4 × l07 tachyzoites and a control inoculum of dmem, respectively. cli...

quercetin is a dietary flavonoid which has anti-inflammatory effects. this study aimed to evaluate the influence of quercetin on histopathological aspects and airway epithelium in  allergic airway  inflammation mice model. twenty-eight balb/c mice were randomly divided into four groups: group i (control), group ii (untreated mice with allergic airway inflammation), group iii (allergic airway in...

introduction: doxorubicin is frequently used for treatment of several types of cancer. doxorubicin cardiac toxicity has limited the use of this drug. corticosteroids may prevent doxorubicin induced cardiotoxicity. therefore the aim of this study was to evaluate mouse embryonic stem cells derived cardiomyocytes as a model to evaluate the effect of doxorubicin and dexamethasone. methods: mouse em...

Human beings have always made their tools and instruments they need using patterns in nature. Mimicking nature has become the foundation of a new science called Biomimetics. In the present article, multiple forms and levels in nature were utilized to design and create a mouse. The rivers are a good source for choosing the shape of a mouse with lots of stones abraded through the centuries which ...

Introduction: Doxorubicin is frequently used for treatment of several types of cancer. Doxorubicin cardiac toxicity has limited the use of this drug. Corticosteroids may prevent doxorubicin induced cardiotoxicity. Therefore the aim of this study was to evaluate mouse embryonic stem cells derived cardiomyocytes as a model to evaluate the effect of Doxorubicin and dexamethasone. Methods: Mouse ...

introduction: helicobacter pylori (h. pylori) is a gastric pathogen of primates and causes active chronic gastritis as well as peptic ulcers. a wide range of studies is in effect to prevent or cure helicobacter infection and thus its associated disorders. in order to test various drug regimens as well as potential vaccines against h. pylori infection, a suitable animal model is required which s...

introduction: multiple sclerosis (ms) is a chronic inflammatory demyelinating disease. in the present study, we investigated the response of subventricular zone (svz) adult stem cells in the experimental autoimmune encephalomyelitis (eae), an animal model of ms, and also the differentiation fate of these stem cells. methods: mice were immunized with mog peptide emulsified in complete freund&apo...

background: cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumors and is one of the cancer treatment strategies. recently, interluekin36 (il36) has been used as immunotherapeutic agents in cancer gene therapy. present study investigated that the il36 gene therapy effects on the regression of tumor masses in mouse model. aim of this study is determination of t...