background: induction of ovulation in art is necessary for superovulation and the side effects of superovulatory drugs are debated. oxytocin as a natural hormone, have receptors and is synthesized by several reproductive organs. preovulatory presence of oxytocin receptor mrnas in granulosa cells indicating a role for oxytocin in follicular development. objective: the aim of the present study wa...

the activity of mouse endometrial alkaline phosphatase after hyperstimulation and progesterone injection at the implantation time alkaline phosphatase (alp) of endometrium may play a critical function in the development and implantation of embryo. the aim of this study was to determine the localization of endometrial alp activity after hyperstimulation and progesterone injection. thirty adult f...

background: the preparation of endometrium for embryo reception and implantation are controlled by ovarian hormones. these hormones have distinct cyclical changes during estrus cycle. objective: the aim of this study was to evaluate the changes in morphology and morphometrical indices of endometrium by daily injections of estrogen and progesterone in ovariectomized mouse. materials and methods:...

Endometrium is a unique tissue that is prepared for implantation of blastocyst during each menstrual cycle by expression of genes during a defined period of endometrial receptivity. Induction of gene over-expression in endometrium allows gaining insight on the role that genes play in endometrial function. Here, we show that induction of a state of gene over-expression in endometrium is feasible...

Human uterine endometrium exhibits unique properties of cyclical regeneration and remodeling throughout reproductive life and also is subject to endometriosis through ectopic implantation of retrogradely shed endometrial fragments during menstruation. Here we show that functional endometrium can be regenerated from singly dispersed human endometrial cells transplanted beneath the kidney capsule...

BACKGROUND Reproductive tissues are unique structures that exhibit cyclic stromal remodelling during menstrual cycles in humans. Ebaf/lefty participates in tissue remodelling of human endometrium by induction of matrix metalloproteases (MMP). METHODS We describe the temporal expression and spatial distribution of lefty and tissue remodelling events in mouse endometrium. RT-PCR and real-time P...

background: the preparation of endometrium for embryo reception is dependent on the ovarian hormones, which are affected by ovarian hyperstimulation procedure. objective: the aim of this study was to evaluate the changes in morphometrical indices of endometrium by the daily injection of progesterone after mouse ovarian induction. materials and methods: adult virgin female mice were selected and...

Abstract Unopposed estradiol and obesity are known risk factors for endometrial adenocarcinoma (EC). Endometrium from women with was found to have an increase in mutations relative tissue normal weight women, indicating DNA damage may be accelerated the setting of obesity. Since is associated high levels insulin anovulatory cycles, we sought mimic these conditions a mouse model. We previously t...

introduction: the aim of this study was to determine mouse endometrium glycocalyx cell surface alteration after ovarian hyperstimulation using hmg, hcg and daily progesterone injection at implantation time. materials and methods: for this purpose adult nmri mice were super ovulated using hmg, hcg and then daily injections of progesterone (1 mg/mouse) performed in one group. the animals were sac...