BACKGROUND Altitude illness results from hypobaric hypoxia at altitudes higher than 2500 meters above sea level. To determine whether vital signs can be used as predictors for severe acute mountain sickness, we carried out a prospective observational study. METHODS A cohort of 90 individuals (male/female ratio: 2; age: 13 - 65 years) in a mountain hotel's clinic at 3450 meters in Iran were st...

BACKGROUND We established a rat model of chronic mountain sickness using acetyl-L-cysteine. Then we studied the effects and mechanisms of acetyl-L-cysteine (Da) in rats with chronic mountain sickness using nuclear magnetic resonance (H1-NMR) metabolomics methods. MATERIAL AND METHODS Using NMR spectroscopy combined with pattern recognition and orthogonal partial least squares discriminant ana...

STUDY OBJECTIVE Acute mountain sickness occurs in more than 25% of the tens of millions of people who travel to high altitude each year. Previous studies on chemoprophylaxis with nonsteroidal anti-inflammatory drugs are limited in their ability to determine efficacy. We compare ibuprofen versus placebo in the prevention of acute mountain sickness incidence and severity on ascent from low to hig...

purpose headache at altitudes has had an incidence of 25-62% through many related studies. many reasons are identified concerning headache at altitudes such as acute mountain sickness (ams), sinus headache, migraine, tension type headache, and frontal tension headache. this study tried to compare different types of headache among trekkers on mount damavand, a 5671m mountain, iran, to find their...

The purpose of the study was to investigate determinants of acute mountain sickness after rapid ascent to high altitude. A total of 21 climbers were studied ascending from <1,200 m to Capanna Regina Margherita, a hut in the Alps at 4,559 m, within <24 h. During their overnight stay at 4,559 m, breathing patterns and ventilation were recorded by calibrated respiratory inductive plethysmography a...

BACKGROUND Rhodiola crenulata (R. crenulata) is widely used to prevent acute mountain sickness in the Himalayan areas and in Tibet, but no scientific studies have previously examined its effectiveness. We conducted a randomized, double-blind, placebo-controlled crossover study to investigate its efficacy in acute mountain sickness prevention. METHODS Healthy adult volunteers were randomized t...

Arias-Stella, J., Kriiger, H., and Recavarren, S. (1973). Thorax, 28, 701-708. Pathology of chronic mountain sickness. Pathological data on chronic mountain sickness are scarce due to the fact that the disease is ameliorated or cured by descent to a low altitude. In this report we describe a case of chronic mountain sickness occurring in a woman of 48 years at Cerro de Pasco (4,300 m above sea ...

OBJECTIVES To assess the efficacy of three different daily doses of acetazolamide in the prevention of acute mountain sickness and to determine the lowest effective dose. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline and Embase along with a hand search of selected bibliographies. No language restrictions were applied. STUDY SELECTION Randomised controlled trials assessi...

We survey old and new regularity theory for the Monge-Ampère equation, show its connection to optimal transportation, and describe the regularity properties of a general class of Monge-Ampère type equations arising in that context.