background: morphine and lidocaine are known to influence the perception of pain. the present study sought to determine the influence of local administration of morphine on lidocaine-induced analgesia in morphine non-dependent (mnd), morphine dependent (md) and morphine withdrawal (mw) animals. methods: adult male wistar rats were divided into four groups: control, mnd, md and mw rats. lidocain...

BACKGROUND Alpha 2 (α(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (α(2)-adrenoceptor agonists) on morphine analgesia and tolerance in rats. METHODS Adult male Wistar albino rats weighing 195-20...

Background: Morphine and lidocaine are known to influence the perception of pain. The present study sought to determine the influence of local administration of morphine on lidocaine-induced analgesia in morphine non-dependent (MND), morphine dependent (MD) and morphine withdrawal (MW) animals. Methods: Adult male Wistar rats were divided into four groups: Control, MND, MD and MW rats. Lidocai...

BACKGROUND Morphine and lidocaine are known to influence the perception of pain. The present study sought to determine the influence of local administration of morphine on lidocaine-induced analgesia in morphine non-dependent (MND), morphine dependent (MD) and morphine withdrawal (MW) animals. METHODS Adult male Wistar rats were divided into four groups: Control, MND, MD and MW rats. Lidocain...

It has been reported that some agents which increase the concentration of catecholamines in brain potentiate morphine analgesia (3). It has also been reported that reserpine which depletes catecholamines from the brain and peripheral tissue antagonizes morphine analgesia (5). Since the role of catecholamines in morphine analgesia is a subject -of great interest, it was thought worthwhile to see...

There are coflicting reports regarding the role of GABA in morphine analgesia. While-sorne investigators have reported that treatment with GABAA receptor agonist muscimol and GABA transaminase inhibitors potentiates morphine analgesia (2.4.6) others have reported antagonism of morphine analgesia (8.10). In view of these conflicting reports and since the analgesic profile 'of THIP, a GABAA recep...

Pain sensitivity reflects a balance between pain facilitatory and inhibitory systems. To characterize the relationships between these systems we examined the interactions between the analgesic effects of morphine and the anti-analgesic effects of the pro-inflammatory cytokine interleukin-1 (IL-1). We report that administration of a neutral dose of IL-1beta abolished morphine analgesia in mice, ...

INTRODUCTION Good analgesia is important after a caesarean section but there are no studies to date that compared intrathecal (IT), epidural (EP) and intravenous patient-controlled analgesia (IV PCA) morphine for post-caesarean section analgesia. In this study, we compared the differences in the quality of analgesia and side effects rendered by IT, EP and IV PCA morphine for post-caesarean sect...

Morphine analgesia in mice was significantly potentiated by pretreatment with 5-hydroxytryptophan (5-HTP), especially with higher dose of morphine. Morphine analgesia was antagonised by reserpine. With l-dopa it was antogonised when the dose of morphine was minimal but with increased dosage of morphine, there was no significant effect.

Opioid and non-opioid mechanisms of analgesia elicited by two kinds of footshock stress that differ only in temporal characteristics previously have been inferred on the basis of susceptibility to naloxone blockade. The present study sought further evidence on this point by comparing these two kinds of footshock analgesia for possible tolerance development and cross-tolerance with morphine. It ...