objective: to evaluate the potential advantages of imipenem/cilastatin in control of fever in neutro-penic hsct recipients.patients and method: in this single-center study, 111 consecutive febrile episodes in 104 neutropenic hsct recipients with a mean age of 26 years were randomized to treatment either with imipenem/cilastatin 1 g, iv, q8h or cefepime (our standard regimen) 2 g, iv, q8h. if fe...

OBJECTIVE According to a recent randomized, double-blind clinical trial comparing the combination of voriconazole and anidulafungin (VOR+ANI) with VOR monotherapy for invasive aspergillosis (IA) in patients with hematologic disease or with hematopoietic stem cell transplant, mortality was lower after 6 weeks with VOR+ANI than with VOR monotherapy in a post hoc analysis of patients with galactom...

Introduction The incidence of beta thalassemia varies greatly in different regions China. Blood transfusion combined with iron chelation and hematopoietic stem cell transplantation (HSCT) is the main treatment for This study aimed to reveal specific schemes used patients evaluate their effects. Methods A search strategy was developed identify articles published between 1 January 2010 30 August ...

background: major thalassemia is the most common form of anemia requiring blood transfusion in iran. since ribavirin provokes anemia in the treated patients, interferon monotherapy may be an appropriate treatment in major thalassemic patients. the aim of this study was to determine the safety and efficacy of interferon monotherapy in thalassemic patients with hepatitis c virus infection. materi...

Imatinib Mesylate (IM) and other tyrosine kinase inhibitor (TKI) therapies have had a major impact on the treatment of chronic myeloid leukemia (CML). However, TKI monotherapy is not curative, with relapse and persistence of leukemic stem cells (LSCs) remaining a challenge. We have recently identified an AHI-1-BCR-ABL-JAK2 protein complex that contributes to the transforming activity of BCR-ABL...

objectives: the aim of this study was to investigate the prevalence and its determinants of antipsychotic use in patients with psychiatric disorders. materials and methods: this study was on patients with psychiatric disorder that have discharged from the hospital. we have assessed all patients with psychiatric interview and evaluation of their psychiatric documentations. results: 90.7% of all ...

BACKGROUND Dose-intensive chemotherapy with hematopoietic stem cell transplantation has been evaluated as a salvage treatment for recurrent ovarian cancer, but its benefit has not yet been demonstrated. In a previous phase I trial, we reported the feasibility of administering topotecan as a salvage regimen. METHODS Twenty-one patients were treated with escalating doses of topotecan associated...

objectives: psychotropic drug use in the elderly with chronic schizophrenia is an important issue in the field of psychiatry. the main goal of this study was to clarify the pattern of such drug use in these patients, in order to consider such therapy plan and focus on its cost attributing measures, for a more reasonable quality of care program. methods: in this descriptive study, participants i...

Background: Topical retinoid based combinations are recommended to enhance the outcome of acne treatment. Adapalene-benzoyl peroxide (BPO) combination gel was approved in 2009 for acne treatment. The aim of this study was to evaluate the efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% combination gel compared to adapalene 0.1% gel monotherapy and benzoyl peroxide 2.5% gel mono...