Alopecia areata occurs more often in Down's syndrome than would be expected by chance, sixty cases being found among 1000 patients with this syndrome compared with one case among 1000 subnormal controls. Because alopecia areata is associated with some organ-specific autoimmune disease and thyroid antibodies are often found in Down's syndrome sera from affected patients were examined for the p...

This is a fascinating study of Mongolism and it is written in a beautifully clear German style. The author makes the assumption that mongols began to appear suddenly in Britain about one hundred years ago. He likens the spread of mongolism to an epidemic and considers that the forces and conditions fruitful for the birth of mongols can be likened to an endemic condition. Although he quotes some...

In his preface (which is over a third of the length of Nigel's own contribution) Mr. Hunt writes with understandable emotion and some lack of objectivity. He certainly seems to have been unfortunate in his experience of 'experts' and some of the statutory services for the mentally handicapped. It would be a pity if members of the general public and the parents of other mongols were persuaded by...

Acute keratoconus is the term applied to the sudden development of a gross degree of corneal oedema in a patient with a pre-existing keratoconus. This rare condition was probably first described by Terrien (I906). An association between mongolism and acute keratoconus has recently been observed, the first two cases having been reported by Hoffmann (I956). Three cases (two bilateral) are reporte...

The Secrete History of the Mongols (SHM) is a special Mongolian historical document transliterated with Chinese characters as phonetic symbols, which feature causes many multivariate analyses in later ages. The discussion of this paper mainly focuses on the data of used Chinese characters, the frequencies, and the rules of transliteration on SHM. All the statistic data and the analysis are base...

In a previous communication (Smith and Record, 1955) it was observed that there appeared to be an association between mongolism and primogeniture which invites investigation of the fertility of mothers of mongols. Such a study is by no means new. It has been attempted by many previous workers, prompted perhaps by the observations that the risk of producing a mongol increases sharply with advanc...