The aim of this study was to evaluate the nutrient digestibility, ruminal fermentation and microbial protein synthesis of mid-lactating cows fed high dietary levels of monensin. Twelve Holstein cows were distributed into four 3 × 3 latin squares and assigned to the following treatments: control (CON), monensin 24 (M24, addition of 24 mg monensin/kg diet DM) and monensin 48 (M48, addition of 48 ...

Toxic effects of monensin, a polyether antibiotic mainly used as a coccidiostat, have been described in a wide range of animals. The present study was performed to investigate the toxic effects of monensin in goats. Seven adult goats were administered sodium monensin, 13.5 mg kg-1, daily for five consecutive days via gastric gavage. Monensin toxicity was evaluated by clinical signs, serum bioch...

in order to surveying the effect of feeding propolis on performance, feed intake and digestibility in holstein suckling calves, the experiment was designed in a completely randomized design with 4 treatments (diet) and 10 replicates (cattle) during 52 days. treatments included: 1. control (without monensin in starter and without propolis in milk); 2. starter without monensin and 500 ppm soluble...

OBJECTIVES To determine the stability/reversibility and mechanism of monensin adaptation in monensin-treated cattle isolates compared with reference bacterial isolates, exposed in vitro to high monensin concentrations. METHODS We evaluated the potential for cattle-origin strains of Clostridium perfringens, Enterococcus faecium and Enterococcus faecalis exposed to monensin in vivo (in vivo mon...

The utilization of carboxylic ionophores such as monensin for immunotoxin potentiation may be hampered by the poor solubility and short in vivo half-life of these highly lipophilic compounds. Therefore, the use of monensin formulated in a lipid/water emulsion was investigated for the in vitro and in vivo potentiation of immunotoxins. Monensin in emulsion or in buffer was equally effective for t...

this study was conducted to evaluate the effect of supplementing diets of milking cows monensin supplementation alone or in combination with methafix (a commercial product containing malate and fumarate) on nutrient digestibility, milk production and composition and milk fatty acids profile. using four multiparous holstein milking cows (657± 12 kg of live weight; 133 ± 41days in milk) in a lati...

There is growing concern about residual antibiotics and feed additives in the manure of treated animals because of the effects of these residues in the environment. Monensin is the most widely used ionophore coccidiostat in the U.S. The objective of this study was to determine the fate and effect of monensin during the anaerobic digestion of dairy manure. Duplicate plug flow field-scale digeste...

Nisin, a bacteriocin, is a potential alternative to antibiotics to modulate rumen fermentation. However, little is known about its impacts on rumen microbes. This study evaluated the effects of nisin (1 and 5 μM) on in vitro rumen fermentation characteristics, microbiota, and select groups of rumen microbes in comparison with monensin (5 μM), one of the most commonly used ionophores in ruminant...

Total and monensin-resistant anaerobic bacterial populations and volatile fatty acid concentrations were examined in the rumens of steers fed monensin-containing (33 mg/kg) and unmedicated diets. Total anaerobic counts on a habitat-simulating medium ranged from 7.1 X 10(8) to 7.1 X 10(9) CFU/g of rumen ingesta and were not significantly different in animals fed the two diets. The mean percentag...