Mometasone furoate, a potent glucocorticoid (class III) with a favorable benefit/risk ratio, has emerged as a standard medication for the treatment of inflammatory skin disorders. The purpose of the investigation presented here was to determine the noninferiority of a topical mometasone formulation, a light cream (O/W 60/40 emulsion) with mometasone furoate 0.1% (water content of 33%) versus ma...

Background Asthma is a problem worldwide, with an estimated 300 million affected individuals. Mometasone being newer drug has low systemic bioavailability, high glucocorticoid receptor affinity and modifies inflammatory mediators involved in the pathogenesis of asthma. Mometasone significantly improves PFT and symptom control in patients with asthma when used in combination with Formoterol. The...

BACKGROUND Although antihistamines and topical corticosteroids are used in combination to treat allergic rhinitis, their additive effect has not been yet demonstrated. The aim was investigate the antiinflammatory additive effect of mometasone and desloratadine on cytokine and sICAM-1 secretion by epithelial cells, and on eosinophil survival stimulated by human epithelial cells secretions from n...

BACKGROUND Topical application of corticosteroids also has an influence on skin barrier impairment. Physiological lipid mixtures, such as multi-lamellar emulsion (MLE) containing a natural lipid component leads to effective recovery of the barrier function. OBJECTIVE The purpose of this study was to conduct an evaluation of the therapeutic efficacy and skin barrier protection of topical momet...

conclusions combination therapy with tretinoin plus topical corticosteroids is safe and effective and provides an alternative in the treatment of patients with vitiligo. objectives recent studies suggest that administration of topical tretinoin, with a corticosteroid, diminishes skin atrophy without impacting the steroid’s anti-inflammatory effects. patients and methods a placebo-controlled, pa...

OBJECTIVE To test the antibacterial properties of the topical corticoid mometasone furoate, which is used as a nasal spray. DESIGN The activity of mometasone (0.01%, 0.1%, and 0.5%) in buffer solution against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Streptococcus pyogenes, and Streptococcus milleri was tested by quantitative killing assays. SETTING In vitro study. ...

BACKGROUND In a previous study, a 200-microg once-daily evening dose of mometasone furoate dry powder inhaler (DPI) was effective in patients with asthma previously taking inhaled corticosteroids. No studies have been conducted to test the effect of a once-daily evening dose in patients previously using only short-acting beta2-adrenergic agonists (SABAs) for symptom relief. OBJECTIVE To evalu...

Tazarotene, the first of new generation receptor selective topical retinoid, currently being investigated and widely used in treatment of mild to moderate psoriasis. The objective of the study is to evaluate the safety and efficacy of topical tazarotene gel 0.1% in comparison with corticosteroid mometasone furoate 0.1% cream in treatment of chronic plaque psoriasis. 50 patients of chronic plaqu...

OBJECTIVE To evaluate the efficacy and safety of mometasone furoate nasal spray (NS) for the treatment of nasal polyposis. DESIGN Randomized, double-blind, placebo-controlled, parallel-group, multicenter study. SETTING A total of 24 centers in 17 countries. PATIENTS A total of 310 subjects 18 years or older with bilateral nasal polyps. INTERVENTIONS (1) A 200-microg dose of mometasone f...

BACKGROUND Inhaled glucocorticoids are efficient in protecting against asthma exacerbations, but methods to compare their efficacy vs systemic effects have only been attempted in larger multi-centre studies. The aim of the current study was therefore to directly compare the effects of two separate inhaled glucocorticoids, mometasone and budesonide, to compare the effects on the early and late a...