Three proteins with similar effects on mitochondrial morphology were identified in an RNA interference (RNAi) screen for mitochondrial abnormalities in Caenorhabditis elegans. One of these is the novel mitochondrial outer membrane protein MOMA-1. The second is the CHCHD3 homologue, CHCH-3, a small intermembrane space protein that may act as a chaperone. The third is a mitofilin homologue, IMMT-...

RppA is a type III polyketide synthase (PKS) that catalyzes condensation of five molecules of malonyl-CoA to form 1,3,6,8-tetrahydroxynaphthalene (THN). In Streptomyces antibioticus IFO13271 and several other Streptomyces species, an open reading frame, named momA, is present as a neighbor of rppA. MomA belonged to the "cupin" superfamily because it contained a set of two motifs that is respons...

Using functional magnetic resonance imaging (fMRI) we investigated whether a culturally defined context modulates the neurocognitive processing of artworks. We presented subjects with paintings from the Museum of Modern Art (MoMA) in New York, and labeled them as being either from the MoMA or from an adult education center. Irrespective of aesthetic appreciation, we found higher neural activati...

Protein-ligand interactions taking place far away from the active site, during ligand binding or release, may determine molecular specificity and activity. However, obtaining information about these interactions with experimental or computational methods remains difficult. The computational tool presented in this article, MoMA-LigPath, is based on a mechanistic representation of the molecular s...

An important goal of whole-cell computational modeling is to integrate detailed biochemical information with biological intuition to produce testable predictions. Based on the premise that prokaryotes such as Escherichia coli have maximized their growth performance along evolution, flux balance analysis (FBA) predicts metabolic flux distributions at steady state by using linear programming. Cor...

The Mars Organic Molecule Analyzer (MOMA) instrument onboard the ESA/Roscosmos ExoMars rover (to launch in July, 2020) will analyze volatile and refractory organic compounds in martian surface and subsurface sediments. In this study, we describe the design, current status of development, and analytical capabilities of the instrument. Data acquired on preliminary MOMA flight-like hardware and ex...

In this article, we provide both analytical and numerical performance analysis of multi-service oriented multiple access (MOMA), a recently proposed non-orthogonal multiple-access scheme for scenarios with a massive number of concurrent connections originating from separate service classes with diverse quality-of-service (QoS) profiles and running on both handheld terminals and Internet-of-Thin...

Thought interoperability has been gaining in importance and become an essential issue within the Semantic Web community, the main challenge of interoperability and data integration is still ontology matching. With this in mind, we wish to contribute to the enhancement of (semantic) interoperability by supporting the ontology matching issue; we propose an evaluation framework for matching approa...

An approach for decreasing costs in lightweight structures using FRP composite materials is applied considering hybrid construction where expensive and high-stiffness materials are used together with inexpensive and low-stiffness material. So, a Multi-objective Memetic Algorithm (MOMA) searching Pareto-optimal front is proposed. The trade-off between minimum weight/sustainable costs and minimum...