Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic bacteria. In some it has been demonstrated that the random switching of the mod (DNA methyltransferase) gene mediates the coordinated expression of multiple genes and constitutes a phasevarion (phase variable regulon). ModA of Neisseria and Haemophilus influenzae contain a highly variable, DNA re...

A new, short, neuropsychologically oriented test for dementia assessment--the Milan Overall Dementia Assessment (MODA)--is described. Age and education adjusted norms based on 217 healthy controls are given. A validation study on 312 outpatients suspected of dementia (121 with probable Alzheimer's disease) showed that the MODA differentiated patients with cognitive impairment from normal subjec...

The suppression of protoplasmic incompatibility resulting from nonallelic gene interactions has been obtained by the coupled effect of mutations in the modA and modB genes (Bernet 1971). Due to their female sterility, modA modB strains provide an experimental tool to determine whether or not the mod and incompatibility loci are involved in a function other than protoplasmic incompatibility. Pre...

Model order deduction algorithms have been developed in an effort to automate the production of accurate, minimal complexity models of dynamic systems in order to aid in the design of these systems. Previous algorithms, MODA and Extended MODA, deduce models independent of system inputs and outputs. FD-MODA uses frequency response methods to deduce models of a single input-output pair. In this p...

We study the homotopy category K(InjA) of all injective A-modules InjA and derived category D(ModA) of the category ModA of all A-modules, where A is finite dimensional algebra over an algebraically closed field. We are interested in the algebra with discrete derived category (derived discrete algebra. For a derived discrete algebra A, we get more concrete properties of K(InjA) and D(ModA). The...

ModA, the periplasmic-binding protein of the Escherichia coli mod transport system was overexpressed and purified. Binding of molybdate and tungstate to ModA was found to modify the UV absorption and fluorescence emission spectra of the protein. Titration of these changes showed that ModA binds molybdate and tungstate in a 1:1 molar ratio. ModA showed an intrinsic fluorescence emission spectrum...

A novel tungstate and molybdate binding protein has been discovered from the hyperthermophilic archaeon Pyrococcus furiosus. This tungstate transport protein A (WtpA) is part of a new ABC transporter system selective for tungstate and molybdate. WtpA has very low sequence similarity with the earlier-characterized transport proteins ModA for molybdate and TupA for tungstate. Its structural gene ...

To improve the ability of engineers to use dynamic models as part of the design process, a model synthesis procedure for developing proper models of hybrid systems is presented. An accuracy criterion and a new search pattern is developed for a model order deduction algorithm (MODA) previously published. The extended MODA process consists of systematically incrementing the rank of each component...

Let A = ⊕ i∈N Ai be a Koszul algebra over a filed K = A0, and *modA the category of finitely generated graded left A-modules. The linearity defect ldA(M) of M ∈ *modA is an invariant defined by Herzog and Iyengar. An exterior algebra E is a Koszul algebra which is the Koszul dual of a polynomial ring. Eisenbud et al. showed that ldE(M) < ∞ for all M ∈ *modE. Improving their result, we show that...

Gene co-expression network differential analysis is designed to help biologists understand gene expression patterns under different conditions. We have implemented an R package called MODA (Module Differential Analysis) for gene co-expression network differential analysis. Based on transcriptomic data, MODA can be used to estimate and construct condition-specific gene co-expression networks, an...