normal pressure hydrocephalus (nph) is characterized by gait apraxia, urinary incontinence, and dementia. mixed connective tissue disease (mctd) is an autoimmune connective tissue disease that has never been reported to cause nph. our patient was a 67-year man with a one-year history of gradual worsening gait and balance, urinary urgency with urge incontinence and decreased short-term memory. p...

the b cell is a vital contributor to humoral immunity. the b cell-specific antigen cd20 is expressed during b cell development, starting at the pre-b cell level and persists through b cell differentiation, but is lost during terminal differentiation to plasma cells. rituximab is a monoclonal antibody that destroys both normal and malignant b cells that have cd20 on their surfaces and is therefo...

Mixed connective tissue disease deserves to be a distinct disease entity due to the persistent citation of this disease in the literature since the original description by Sharp in 1972, in spite of the presence of several criticisms against the independency of this disease. The characteristic features of mixed connective tissue disease are: 1) the presence of anti-U1snRNP antibody with high ti...